Table 6. Overview of Standard Treatment Options for Stage III Wilms Tumora

Histology4-Year RFS or EFS4-Year OSTreatment (refer to Table 2 for chemotherapy regimen descriptions)
FH (all patients)88% EFS97%Nephrectomy + lymph node sampling followed by abdominal XRT and regimen DD-4A
FH (without LOH of 1p and/or 16q) and positive lymph nodes85% EFS97%Nephrectomy + lymph node sampling followed by abdominal XRT and regimen DD-4A
FH (without LOH of 1p and/or 16q) and negative lymph nodes97% EFS99%Nephrectomy + lymph node sampling followed by abdominal XRT and regimen DD-4A
FH (with LOH of 1p and 16q) (n = 31)87% EFS94%Nephrectomy + lymph node sampling followed by abdominal XRT and regimen M
FA88% RFS100% (n = 8)Nephrectomy + lymph node sampling followed by abdominal XRT and regimen DD-4A
FA (preoperative treatment)71% RFS71% (n = 7)Preoperative treatment with regimen DD-4A followed by nephrectomy + lymph node sampling and abdominal XRT
DA 46% EFS53% (n = 16)Preoperative treatment with regimen I followed by nephrectomy + lymph node sampling and abdominal XRT
DA82% EFS91% (n = 23)Immediate nephrectomy + lymph node sampling followed by abdominal XRT and regimen UH1

DA = diffuse anaplastic; EFS = event-free survival; FA = focal anaplastic; FH = favorable histology; LOH = loss of heterozygosity; OS = overall survival; RFS = relapse-free survival; XRT = radiation therapy.

aSource: Grundy et al.,[101] Dome et al.,[152] Fernandez et al.,[233] Dix et al.,[220] and Daw et al.[223]

From: Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®)

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PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.
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