Table 5. Overview of Standard Treatment Options for Stage II Wilms Tumora

Histology4-Year RFS or EFS4-Year OSTreatment (refer to Table 2 for chemotherapy regimen descriptions)
FH86% RFS98%Nephrectomy + lymph node sampling followed by regimen EE-4A
FH LOH 1p/16q (n = 24)83% EFS100%Nephrectomy + lymph node sampling followed by regimen DD-4A
FA 80% EFS80% (n = 5)Nephrectomy + lymph node sampling followed by abdominal XRT and regimen DD-4A
DA84% EFS 84% (n = 19)Nephrectomy + lymph node sampling followed by abdominal XRT and regimen UH1

DA = diffuse anaplastic; EFS = event-free survival; FA = focal anaplastic; FH = favorable histology; LOH = loss of heterozygosity; OS = overall survival; RFS = relapse-free survival; XRT = radiation therapy.

aSource: Grundy et al.,[101] Dome et al.,[152] Dix et al.,[220] and Daw et al.[223]

From: Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®)

Cover of PDQ Cancer Information Summaries
PDQ Cancer Information Summaries [Internet].
Bethesda (MD): National Cancer Institute (US); 2002-.

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