Table 6Summary of studies included in the evidence review

StudyRisk factorPopulationOutcomes (including definitions)No. of event (n)
Buratti 2021 (Buratti, Crimi, Somaschini, Cornara, Camporotondo, Cosentino, Moltrasio, Rubino, De Metrio, Marana, De Servi, Marenzi and De Ferrari, 2021) eGFR
  • <60

N=1954

Consecutive STEMI patients undergoing PCI

Mean age (SD): 62.48 (12.14) years

Italy

Contrast-induced AKI, defined as: an absolute serum creatinine increase ≥0.5 mg/dl in the first 72 hours93 (4.8%)
Caspi 2017 (Caspi, Habib, Cohen, Kerner, Roguin, Abergel, Boulos, Kapeliovich, Beyar, Nikolsky and Aronson, 2017) eGFR:
  • <30
  • 30-59

N=2025

Patients admitted with STEMI undergoing PCI

Mean age (SD): 59.72 (12.93) years

Israel

Increase in serum creatinine concentration ≥0.5 mg/dL compared with admission value or a >25% relative rise during the first 72 hours after the procedure209 (10.3%)
Liu 2015 (Liu, He, Tan, Chen, Liu, Yang, Huang, Ye, Li, Ran, Duan, Chen, Zhou and Chen, 2015) eGFR:
  • <60

N=2248

Consecutive patients undergoing coronary angiography or PCI

Mean age (SD): 63.48 (10.72) years

China

Increase in serum creatinine of >0.5 mg/ dL over the baseline value within 48 to 72 hours after the administration of contrast medium50 (2.2%)
Lunyera 2021 (Lunyera, Clare, Chiswell, Scialla, Pun, Thomas, Starks and Diamantidis, 2021) eGFR:
  • <15
  • 15-29
  • 30-59

N=9422

Patients undergoing cardiac catheterization and cardiac surgery

Mean age (IQR): 62 (54-72)

USA

KDIGO criteria: a 1.5-fold or greater relative elevation in serum creatinine from the reference value to the highest value within 7 days after the date and time of PCI, or a 0.3 mg/dl absolute increase in serum creatinine from the reference value within 48 hours after the date and time of PCI865 (9%)
Mohebi 2022 (Mohebi, Karimi Galougahi, Garcia, Horst, Ben-Yehuda, Radhakrishnan, Chertow, Jeremias, Cohen, Cohen, Maehara, Mintz, Chen, Redfors, Leon, Stuckey, Rinaldi, Weisz, Witzenbichler, Kirtane, Mehran, Dangas, Stone and Ali, 2022) eGFR:
  • <60

N=7287

Consecutive patients successfully treated with drug-eluting stents

Mean age (SD): 63.84 (10.85) years

USA and Germany

European Society of Urogenital Radiology definition: absolute increase of ≥0.5 mg/dL or ≥25% relative increase in serum creatinine after PCI compared with the pre-PCI serum creatinine level occurring within 3 days of the intravascular administration of contrast medium when no alternative aetiology for AKI was identified476 (6.5%)
Shacham 2016 (Shacham, Gal-Oz, Flint, Keren and Arbel, 2016) eGFR:
  • ≤60

N=1372

Consecutive patients referred with STEMI undergoing primary PCI

Mean age (SD): 61.50 (12.83) years

Israel

AKI network criteria - a rise in serum creatinine >0.3 mg/dl, compared with the admission value153 (11%)

From: Evidence review for risk prediction tools and eGFR for the prediction of iodine-based contrast media-associated acute kidney injury

Cover of Evidence review for risk prediction tools and eGFR for the prediction of iodine-based contrast media-associated acute kidney injury
Evidence review for risk prediction tools and eGFR for the prediction of iodine-based contrast media-associated acute kidney injury: Acute Kidney Injury (update): Evidence review B.
NICE Guideline, No. 148.
Copyright © NICE 2024.

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