| Risk tool | No of studies | n | Risk of bias | Inconsistency | Indirectness | Imprecision | Mean effect size (95% CI) | GRADE overall quality |
|---|---|---|---|---|---|---|---|---|
| Mehran risk score | 1 | 891 | High1 | NA | High2 | High3 | AUC= 0.74 (0.59-0.79) | VERY LOW |
| Mehran risk score (medium risk) vs low risk | 1 | 891 | High1 | NA | High2 | Low | HR= 3.61 (2.19-5.98) | LOW |
| Mehran risk score (high risk) vs low risk | 1 | 891 | High1 | NA | High2 | Low | HR= 8.00 (4.53-14.13) | LOW |
| Mehran risk score (very high risk) vs low risk | 1 | 891 | High1 | NA | High2 | Low | HR= 15.29 (8.11-28.83) | LOW |
| Marenzi risk score | 1 | 891 | High1 | NA | High2 | Low | AUC= 0.60 (0.55-0.65) | LOW |
| GRACE score (<136) | 1 | 251 | Very high4 | NA | Not serious | Low | Sensitivity= 0% (0-31) | LOW |
| Very high4 | NA | Not serious | Low | Specificity= 75% (69-80) | LOW | |||
| GRACE score (136-158) | 1 | 251 | Very high4 | NA | Not serious | Low | Sensitivity= 20% (3-56) | LOW |
| Very high4 | NA | Not serious | Low | Specificity= 75% (69-80) | LOW | |||
| GRACE score (159-180) | 1 | 251 | Very high4 | NA | Not serious | Low | Sensitivity= 20% (3-56) | LOW |
| Very high4 | NA | Not serious | Low | Specificity= 74% (68-80) | LOW | |||
| GRACE score (>180) | 1 | 251 | Very high4 | NA | Not serious | Very serious5 | Sensitivity= 60% (26-88) | VERY LOW |
| Very high4 | NA | Not serious | Serious6 | Specificity= 76% (70-82) | VERY LOW |
Downgraded by one increment due to very high risk of bias arising from the PROBAST risk of bias tool, namely due to unclear timing of the assessment of predictors relative to outcome assessment and concerns arising from the analysis method (discrimination reported without calibration)
Downgraded by one increment due to high levels of concern surrounding the applicability of the risk prediction tool (not all predictors available at the intended time of assessment (prior to contrast administration))
Downgraded by one increment due to the 95%CI overlapping the upper threshold for decision making (0.70)
Downgraded by two increments due to very high risk of bias arising from multiple domains of the PROBAST risk of bias tool, namely due to unclear definitions and assessments of predictors (timing and criteria not specified), inadequate sample size (<100 events) and incomplete analysis reporting (discrimination reported without calibration)
Downgraded by two increments due to the 95%CI overlapping both the threshold corresponding to ‘low sensitivity’ (60%) and ‘high sensitivity’ (80%)
Downgraded by one increment due to the 95%CI overlapping the threshold corresponding to ‘low specificity’ (80%)
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