- Sildenafil did not prolong pregnancy in severe early-onset IUGR compared to placebo.
- Sildenafil did not improve perinatal outcomes in severe early-onset IUGR.
- Sildenafil did not improve maternal cardiovascular parameters in severe early-onset IUGR.
- Sildenafil did not affect infant neurodevelopmental function at age 2 years.
- Sildenafil did not affect infant emotional or behavioural status at age 2 years.
Publication Details
Copyright
This work was produced by Sharp et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This is an Open Access publication distributed under the terms of the Creative Commons Attribution CC BY 4.0 licence, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. See: https://creativecommons.org/licenses/by/4.0/. For attribution the title, original author(s), the publication source – NIHR Journals Library, and the DOI of the publication must be cited.
Publisher
National Institute for Health and Care Research, Southampton (UK)
NLM Citation
Sharp A, Cornforth C, Jackson R, et al. The efficacy of sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction: the STRIDER RCT. Southampton (UK): National Institute for Health and Care Research; 2024 Oct. (Efficacy and Mechanism Evaluation, No. 11.18.) Chapter 6, Summary of key findings.