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Sharp A, Cornforth C, Jackson R, et al. The efficacy of sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction: the STRIDER RCT. Southampton (UK): National Institute for Health and Care Research; 2024 Oct. (Efficacy and Mechanism Evaluation, No. 11.18.)

Chapter 6Summary of key findings

  • Sildenafil did not prolong pregnancy in severe early-onset IUGR compared to placebo.
  • Sildenafil did not improve perinatal outcomes in severe early-onset IUGR.
  • Sildenafil did not improve maternal cardiovascular parameters in severe early-onset IUGR.
  • Sildenafil did not affect infant neurodevelopmental function at age 2 years.
  • Sildenafil did not affect infant emotional or behavioural status at age 2 years.
Copyright © 2024 Sharp et al.

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Bookshelf ID: NBK609314
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