TABLE 5

All-cause mortality at 28 days in the standard arm and in the early cryoprecipitate arm by timing of first cryoprecipitate dose

Cryoprecipitate administered atMortality rate, n/N (%)Relative risk (95% CI)aOR (95% CI)ap-valueb
Standard care arm201/771 (26.1)1.001.00
Intervention arm ≤ 45 minutes from admission33/96 (34.4)1.29 (0.94 to 1.77)1.45 (0.91 to 2.31)0.1195
Intervention arm 46–60 minutes from admission42/144 (29.2)1.11 (0.84 to 1.48)1.16 (0.78 to 1.73)0.4550
Intervention arm 61–90 minutes from admission44/267 (16.5)0.65 (0.46 to 0.91)0.57 (0.38 to 0.87)0.0093
Intervention arm > 90 minutes from admission31/123 (25.2)1.00 (0.71 to 1.41)1.00 (0.62 to 1.60)0.9870
a

Cryoprecipitate administered in the time period relative to standard arm overall, adjusted for centre.

b

Wald test p-value from logistic regression model, adjusted for centre.

Note

Participants for whom 28-day vital status was not available were not included in this analysis, in addition to 130 participants excluded due to missing timing of cryoprecipitate.

From: Chapter 3, Results

Cover of Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis
Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis.
Health Technology Assessment, No. 28.76.
Curry N, Davenport R, Thomas H, et al.
Copyright © 2024 Curry et al.

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