TABLE 4

Primary outcome

OutcomeStandard care arm (n = 805)Intervention arm (n = 799)Overall (n = 1604)p-value
Participants who died on or before day 28 from admission, n/N (%)201/771 (26.1)192/760 (25.3)393/1531 (25.7)
Relative riska (95% CI)0.97 (0.81 to 1.17)
ORb (95% CI)0.96 (0.75 to 1.23)0.7406
OR also adjusted for participant factorsc (95% CI)1.15 (0.93 to 1.42)
Participants for whom 28-day vital status was not available from any source, n/N (%)34/805 (4.2)39/799 (4.9)73/1604 (4.6)
a

Intervention arm relative to standard care arm, adjusted for centre.

b

Intervention arm relative to standard care arm, adjusted for centre; p-value for treatment term in mixed logistic regression model.

c

Intervention arm relative to standard care arm adjusted for centre and significant participant factors.

Notes

Participants for whom 28-day vital status was not available were not included in this analysis. No participants were excluded for other reasons.

Shaded cells are used where the metric is not relevant or where a formal hypothesis test was not planned in the SAP and therefore a p-value is not presented.

From: Chapter 3, Results

Cover of Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis
Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis.
Health Technology Assessment, No. 28.76.
Curry N, Davenport R, Thomas H, et al.
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