Table 1.

The FDA (2019) Drug Label for Clobazam: Recommended Total Daily Dosing by Weight Group

Less than or equal to 30 kg body weightGreater than 30 kg body weightCYP2C19 poor metabolizers
Starting dose5 mg10 mgIn patients known to be CYP2C19 poor metabolizers, the starting dose should be 5 mg/day and dose titration should proceed slowly according to weight, but to half the recommended total daily doses presented in this table, as tolerated. If necessary, and based upon clinical response, an additional titration to the maximum dose (20 mg/day or 40 mg/day, depending on the weight group) may be started on day 21.
Starting day 710 mg20 mg
Starting day 1420 mg40 mg

From: Clobazam Therapy and CYP2C19 Genotype

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