Table 9.4

Effect of various antithrombotic drugs on activated clotting time

DrugXa:IIa activityEffect on ACTTarget ACT (s)
UFH1:1Linear ↑GPI, 300–350 (Hemochron), 250–300 (HemoTech)
No GPI, 200–250 (any device)
Enoxaparin4:1Modest ↑None defineda
FondaparinuxPure XaNo effectNo recommendation
BivalirudinPure IIaDisproportionate ↑No recommendationb

UFH unfractionated heparin, ACT activated clotting time, GPI glycoprotein IIb/IIIa inhibitor

aSee text for recommendations

bACT levels do not correlate with therapeutic efficacy; only an indicator of drug delivery

From: Chapter 9, Anticoagulants and Primary PCI

Cover of Primary Angioplasty
Primary Angioplasty: A Practical Guide [Internet].
Watson TJ, Ong PJL, Tcheng JE, editors.
Singapore: Springer; 2018.
Copyright 2018, The Author(s)

Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

The images or other third party material in this chapter are included in the chapter's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.