Table 1.

The FDA (2017) Drug Label for Flurbiprofen. Poor Metabolizers of CYP2C9 Substrates.

PhenotypeRecommendations
CYP2C9 Poor metabolizersIn patients who are known or suspected to be poor CYP2C9 metabolizers based on genotype or previous history/experience with other CYP2C9 substrates (such as warfarin and phenytoin), reduce the dose of flurbiprofen to avoid abnormally high plasma levels due to reduced metabolic clearance.

This table is adapted from (1).

From: Flurbiprofen Therapy and CYP2C9 Genotype

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Pratt VM, Scott SA, Pirmohamed M, et al., editors.
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