Table 17.1, GRADE evidence profile for early discharge with continued inpatient care - Neutropenic Sepsis: Prevention and Management of Neutropenic Sepsis in Cancer Patients

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Quality assessment							No of patients		Effect		Quality
No of studies	Design	Limitations	Inconsistency	Indirectness	Imprecision	Other considerations	Early discharge	Continued inpatient care	Relative (95% CI)	Absolute	Quality
Short term mortality in paediatric observational studies
11	observational studies¹	no serious limitations	no serious inconsistency	no serious indirectness	serious²	none	0/934 (0%)	-	-	-	VERY LOW
Hospital readmission in paediatric observational studies
9	observational studies¹	no serious limitations	no serious inconsistency	no serious indirectness	serious³	none	42/889 (4.7%)	-	-	-	VERY LOW
Short term mortality in adult case series using MASCC ≥ 21 as criteria for early discharge
3	observational studies	no serious limitations	no serious inconsistency	no serious indirectness	very serious³	none	0/215 (0%)	-	-	-	VERY LOW
Hospital readmission in adult case series using MASCC ≥ 21 as criteria for early discharge
3	observational studies¹	no serious limitations	no serious inconsistency	no serious indirectness	serious³	none	8/215 (3.7%)	-	-	-	VERY LOW
Short term mortality in paediatric RCT (Santolaya, et al., 2004)
1	randomised trials	serious⁴	no serious inconsistency	no serious indirectness	serious³	none	0/78 (0%)	1/71 (1.4%)	-	-	LOW
Short term mortality in adult RCT (Innes, et al., 2003)
1	randomised trials	serious⁴	no serious inconsistency	no serious indirectness	serious³	none	0/66	0/60	-	-	LOW
Overtreatment - not reported
0	-	-	-	-	-	none	-	-	-	-
Quality of life - not reported
0	-	-	-	-	-	none	-	-	-	-
Adverse events - not reported
0	-	-	-	-	-	none	-	-	-	-

1: Case series
2: Case series
3: Low number of events
4: Method of randomisation was unclear. No blinding (but this was unlikely to affect outcome

Neutropenic Sepsis: Prevention and Management of Neutropenic Sepsis in Cancer Patients.

NICE Clinical Guidelines, No. 151.

National Collaborating Centre for Cancer (UK).

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