Table 2.

DPWG (2017) Recommendations for Carbamazepine and HLA Genotype.

GenotypeRecommendations
HLA-B*15:02 positiveChoose an alternative if possible
HLA-A*31:01 positive
1.

carefully weigh the risk of DRESS and SJS/TEN against the benefits

2.

if an alternative is an option, choose an alternative

HLA-B*15:11 positive
1.

carefully weigh the risk of SJS/TEN against the benefits

2.

if an alternative is an option, choose an alternative

Please see Therapeutic Recommendations based on Genotype for more information from DPWG. This table is adapted from (2).

From: Carbamazepine Therapy and HLA Genotype

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Medical Genetics Summaries [Internet].
Pratt VM, Scott SA, Pirmohamed M, et al., editors.
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