Table 6.

CPIC (2017). Assignment of likely HLA-B and HLA-A genotype

GenotypeDefinitionExamples of diplotypes
HLA-B*15:02 negativeHomozygous for an allele other than HLA-A*15:02 *X/*Xa
HLA-B*15:02 positiveHeterozygous or homozygous variant *15:02/*Xa, *15:02/*15:02
HLA-A*31:01 negativeHomozygous for an allele other than HLA-A*31:01 *Yb/*Yb
HLA-A*31:01 positiveHeterozygous or homozygous variant 31:01/*Yb, *31:01/*31:01
a

Where *X 5 any HLA-B allele other than HLA-B*15:02.
bWhere *Y 5 any HLA-A allele other than HLA-A*31:01.

Table is adapted from Phillips EJ, Sukasem C, Whirl-Carrillo M, Müller DJ, Dunnenberger HM, Chantratita W, Goldspiel B, Chen YT, Carleton BC, George ALJ, Mushiroda T, Klein T, Gammal RS, and Pirmohamed M. Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update. Clinical pharmacology and therapeutics (4).

From: Carbamazepine Therapy and HLA Genotype

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