Table 2. [Malignant Neoplasms Diagnosed in Persons in the Bloom Syndrome Registry (1954-2022)]. - GeneReviews®

Malignancy Type/Tissue	Subtype	Frequency	Age at Diagnosis (Years)
Leukemia	Acute myeloid	22	18	18	2-39
Acute lymphoblastic	13	15	18	4-40
Other/biphenotypic/undefined	6	16	18	4-39
Lymphoma	--	42	23	23	4-49
Oropharyngeal	Tongue	10	39	40	30-48
Pharynx	7	32	34	30-45
Tonsil	4	39.5	37.5	25-46
Other	7	31	30	25-34
Upper GI	Esophageal	5	39	37	25-48
Gastric	7	27	30	21-49
Other	1	NA	NA	NA
Colorectal	--	30	36	35	16-49
Genitourinary	Cervical	5	22	22	19-23
Testicular	3	22	19	10-26
Other	6	41	42	33-54
Breast	--	29	32	33	18-52
Skin	Basal cell	18	32	33	18-55
Squamous cell (uncategorized)	8	35	34	25-42
Other/undefined	3	35	34	25-42
Wilms tumor	--	9	3	4	1-11
Lung	--	4	36.5	36	32-40
All other	--	8	NA	NA	NA

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Adam MP, Feldman J, Mirzaa GM, et al., editors.

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