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Perferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Compl...
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Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants[OXIDOREDUCTA...
Human dihydrofolate reductase Q35K mutant inhibitor complex[OXIDOREDUCTASE]
Correlations of Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes[OXIDOREDUCTASE]
COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE[OXIDOREDUCTASE]
STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4-DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS[OXIDOREDUCTASE]
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Human Dihydrofolate Reductase Structural Data with Active Site Mutant Enzyme Complexes[OXIDOREDUCTASE]
Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase[OXIDOREDUCTASE]
human dihydrofolate reductase Q35K/N64F double mutant binary complex with trimethoprim[OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR]
Human dihydrofolate reductase Q35K/N64F double mutant inhibitor complex[OXIDOREDUCTASE]
hDHFR double mutant Q35S/N64F Trimethoprim Binary Complex[OXIDOREDUCTASE]
Structural and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Thier Active Site Mutants[OXIDOREDUCTASE/INHIBITOR]
Structural Data for Human Active Site Mutant Enzyme Complexes[OXIDOREDUCTASE]
Alternate Binding Modes Observed for the E- and Z-Isomers of 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Mouse Dihydrofolate Reductase[OXIDOREDUCTASE]
Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex with the Potent and Selective Inhibitor 2.4-Diamino-6-(-2'-hydroxydibenz[b,f]azepin-5-yl)...
Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex wtih the Potent and Selective Inhibitor 2,4-Diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)m...
New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives[OXIDOREDUCTASE]
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