3T8W: A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

PDB ID: 3T8WDownload
MMDB ID: 93909
PDB Deposition Date: 2011/8/1
Updated in MMDB: 2011/09
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3T8W: hexameric; determined by author and by software (PISA)
Molecular Components in 3T8W
Label Count Molecule
Proteins (6 molecules)
6
M17 Leucyl Aminopeptidase
Molecule annotation
Chemicals and Non-standard biopolymers (51 molecules)
1
6
CARBONATE IONCARBONATE ION
2
12
ZINC IONZINC ION
3
6
N-((2R,3S,6S,18S,21S)-2-amino-18-(4-benzoylbenzyl)-21-carbamoyl-3-hydroxy-6-(naphthalen-2-ylmethyl)-4,7,16,19-tetraoxo-1-phenyl-11,14-dioxa-5,8,17,20-tetraazapentacosan-25-yl)hex-5-ynamideN-((2R,3S,6S,18S,21S)-2-amino-18-(4-benzoylbenzyl)-21-carbamoyl-3-hydroxy-6-(naphthalen-2-ylmethyl)-4,7,16,19-tetraoxo-1-phenyl-11,14-dioxa-5,8,17,20-tetraazapentacosan-25-yl)hex-5-ynamide
4
12
SULFATE IONSULFATE ION
5
14
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
6
1
NONAETHYLENE GLYCOLNONAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303