3LEA: Crystal structure of the catalytic domain of TACE with Isoindolinone-biphenyl-hydantoin inhibitor

PDB ID: 3LEADownload
MMDB ID: 87147
PDB Deposition Date: 2010/1/14
Updated in MMDB: 2010/12
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3LEA: monomeric; determined by author and by software (PISA)
Molecular Components in 3LEA
Label Count Molecule
Protein (1 molecule)
1
Disintegrin and Metalloproteinase Domain-containing Protein 17
(Gene symbol: ADAM17)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
2-{[(4R)-2,5-dioxo-4-(4-pyridin-3-ylphenyl)imidazolidin-4-yl]methyl}-6-methoxy-1-oxo-1H-isoindolium2-{[(4R)-2,5-dioxo-4-(4-pyridin-3-ylphenyl)imidazolidin-4-yl]methyl}-6-methoxy-1-oxo-1H-isoindolium
2
1
ZINC IONZINC ION
3
1
ISOPROPYL ALCOHOLISOPROPYL ALCOHOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303