8I5X: Structure of human Nav1.7 in complex with Vinpocetine

PDB ID: 8I5XDownload
MMDB ID: 231734
PDB Deposition Date: 2023/1/26
Updated in MMDB: 2023/11
Experimental Method:
electron microscopy
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 8I5X: trimeric; determined by author
Molecular Components in 8I5X
Label Count Molecule
Proteins (3 molecules)
1
Sodium Channel Protein Type 9 Subunit Alpha
(Gene symbol: SCN9A)
Molecule annotation
1
Sodium Channel Subunit Beta-1
(Gene symbol: SCN1B)
Molecule annotation
1
Sodium Channel Subunit Beta-2
(Gene symbol: SCN2B)
Molecule annotation
Chemicals and Non-standard biopolymers (35 molecules)
1
11
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serineO-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
3
5
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
4
1
(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
5
1
VinpocetineVinpocetine
6
11
1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE
7
5
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303