7U24: Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide with Kir6.2-CTD in the up conformation

PDB ID: 7U24Download
MMDB ID: 219731
PDB Deposition Date: 2022/2/23
Updated in MMDB: 2022/09
Experimental Method:
electron microscopy
Resolution: 3.58  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 7U24: pentameric; determined by author
Molecular Components in 7U24
Label Count Molecule
Proteins (5 molecules)
4
Atp-sensitive Inward Rectifier Potassium Channel 11
Molecule annotation
1
Atp-binding Cassette Sub-family C Member 8
Molecule annotation
Chemicals and Non-standard biopolymers (25 molecules)
1
5
ADENOSINE-5'-TRIPHOSPHATE (Link to PubChem not yet available)ADENOSINE-5'-TRIPHOSPHATE
2
5
PHOSPHATIDYLETHANOLAMINE (Link to PubChem not yet available)PHOSPHATIDYLETHANOLAMINE
3
4
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (Link to PubChem not yet available)(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
4
9
O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine (Link to PubChem not yet available)O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
5
1
5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (Link to PubChem not yet available)5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
6
1
2-acetamido-2-deoxy-beta-D-glucopyranose (Link to PubChem not yet available)2-acetamido-2-deoxy-beta-D-glucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303