7CE4: Tankyrase2 catalytic domain in complex with K-476

PDB ID: 7CE4Download
MMDB ID: 201888
PDB Deposition Date: 2020/6/22
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 7CE4: dimeric; determined by author and by software (PISA)
Molecular Components in 7CE4
Label Count Molecule
Proteins (2 molecules)
1
Poly [adp-ribose] Polymerase Tankyrase-2
(Gene symbol: TNKS2)
Molecule annotation
1
Poly [adp-ribose] Polymerase Tankyrase-2
(Gene symbol: TNKS2)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
ZINC IONZINC ION
2
2
SULFATE IONSULFATE ION
3
1
5-[3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-2-oxidanylidene-4H-quinazolin-1-yl]-2-fluoranyl-benzenecarbonitrile5-[3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-2-oxidanylidene-4H-quinazolin-1-yl]-2-fluoranyl-benzenecarbonitrile
4
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303