6VG0: CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ISOCITRATE DEHYDROGENASE (IDH1) R132H MUTANT IN COMPLEX WITH NADPH and AGI-15056

PDB ID: 6VG0Download
MMDB ID: 183957
PDB Deposition Date: 2020/1/7
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.66  Å
Source Organism:
Similar Structures:
Biological Unit for 6VG0: dimeric; determined by author and by software (PISA)
Molecular Components in 6VG0
Label Count Molecule
Proteins (2 molecules)
2
Isocitrate Dehydrogenase [nadp] Cytoplasmic
(Gene symbol: IDH1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
1
N~2~,N~4~-bis[(1R)-1-cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamineN~2~,N~4~-bis[(1R)-1-cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303