6AVO: Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes

PDB ID: 6AVODownload
MMDB ID: 157112
PDB Deposition Date: 2017/9/4
Updated in MMDB: 2019/12
Experimental Method:
electron microscopy
Resolution: 3.8  Å
Source Organism:
Similar Structures:
Biological Unit for 6AVO: 28-meric; determined by author
Molecular Components in 6AVO
Label Count Molecule
Proteins (28 molecules)
2
Proteasome Subunit Beta Type-9
(Gene symbol: PSMB9)
Molecule annotation
2
Proteasome Subunit Beta Type-10
(Gene symbol: PSMB10)
Molecule annotation
2
Proteasome Subunit Beta Type-8
(Gene symbol: PSMB8)
Molecule annotation
2
Proteasome Subunit Alpha Type-1
(Gene symbol: PSMA1)
Molecule annotation
2
Proteasome Subunit Alpha Type-5
(Gene symbol: PSMA5)
Molecule annotation
2
Proteasome Subunit Alpha Type-7
(Gene symbol: PSMA7)
Molecule annotation
2
Proteasome Subunit Alpha Type-3
(Gene symbol: PSMA3)
Molecule annotation
2
Proteasome Subunit Alpha Type-6
(Gene symbol: PSMA6)
Molecule annotation
2
Proteasome Subunit Alpha Type-4
(Gene symbol: PSMA4)
Molecule annotation
2
Proteasome Subunit Alpha Type-2
(Gene symbol: PSMA2)
Molecule annotation
2
Proteasome Subunit Beta Type-1
(Gene symbol: PSMB1)
Molecule annotation
2
Proteasome Subunit Beta Type-2
(Gene symbol: PSMB2)
Molecule annotation
2
Proteasome Subunit Beta Type-3
(Gene symbol: PSMB3)
Molecule annotation
2
Proteasome Subunit Beta Type-4
(Gene symbol: PSMB4)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
N~1~-{2-[([1,1'-biphenyl]-3-carbonyl)amino]ethyl}-N~4~-tert-butyl-N~2~-(3-phenylpropanoyl)-L-aspartamideN~1~-{2-[([1,1'-biphenyl]-3-carbonyl)amino]ethyl}-N~4~-tert-butyl-N~2~-(3-phenylpropanoyl)-L-aspartamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303