5SWO: Crystal Structure of PI3Kalpha in complex with fragments 4 and 19

PDB ID: 5SWODownload
MMDB ID: 147365
PDB Deposition Date: 2016/8/8
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 3.5  Å
Source Organism:
Similar Structures:
Biological Unit for 5SWO: dimeric; determined by author and by software (PISA)
Molecular Components in 5SWO
Label Count Molecule
Proteins (2 molecules)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Alpha Isoform
(Gene symbol: PIK3CA)
Molecule annotation
1
Phosphatidylinositol 3-kinase Regulatory Subunit Alpha
(Gene symbol: PIK3R1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
CHLORIDE IONCHLORIDE ION
2
1
2-methyl-5-nitro-1H-indole2-methyl-5-nitro-1H-indole
3
1
4-methyl-3-nitropyridin-2-amine4-methyl-3-nitropyridin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303