5U1X: Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist JNJ47965567

PDB ID: 5U1XDownload
MMDB ID: 146137
PDB Deposition Date: 2016/11/29
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 3.201  Å
Source Organism:
Similar Structures:
Biological Unit for 5U1X: trimeric; determined by author and by software (PISA)
Molecular Components in 5U1X
Label Count Molecule
Proteins (3 molecules)
3
P2X Purinoceptor
(Gene symbol: P2RX7)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
10
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamideN-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303