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2ZMD:
Crystal structure of human Mps1 catalytic domain T686A mutant in complex with SP600125 inhibitor
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PDB ID:
2ZMD
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MMDB ID:
64436
PDB Deposition Date:
2008/4/16
Updated in MMDB:
2023/11
Experimental Method:
x-ray diffraction
Resolution:
2.88 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Default Biological Unit
All Biological Units (2)
Asymmetric Unit
Biological Unit for 2ZMD: monomeric; determined by author
Molecular Graphic
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Interactions
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A
A: Dual specificity protein kinase TTK
1
537: 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE
2
7PE: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
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Format:
ASN.1 (Cn3D)
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Data Set:
alpha-Carbons
Single 3D structure
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Molecular Components in 2ZMD
Label
Count
Molecule
Protein (1 molecule)
A
1
Dual Specificity Protein Kinase TTK
(Gene symbol:
TTK
)
1 Protein
SS Diagram
3D Domains
1
75
150
225
300
390
390 residues, click to see VAST similar structures.
helix 95-111
helix 154-174
helix 247-261
helix 273-281
helix 295-305
helix 314-321
strand 50-54
strand 55-60
strand 61-67
strand 69-77
strand 81-90
strand 120-128
strand 129-136
strand 139-142
strand 185-190
strand 191-196
Domain 1 (1-137): click to see VAST similar structures
1
Domain 2 (138-221): click to see VAST similar structures
2
Domain 3 (222-390): click to see VAST similar structures
3
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Chemicals and Non-standard biopolymers (2 molecules)
1
1
2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE
2
1
2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
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Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303
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