5I9I: Crystal structure of LP_PLA2 in complex with Darapladib

PDB ID: 5I9IDownload
MMDB ID: 140112
PDB Deposition Date: 2016/2/20
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 5I9I: monomeric; determined by author and by software (PISA)
Molecular Components in 5I9I
Label Count Molecule
Protein (1 molecule)
1
Platelet-activating Factor Acetylhydrolase
(Gene symbol: PLA2G7)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[2-(diethylamino)ethyl]-2-{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}-N-{[ 4'-(trifluoromethyl)biphenyl-4-yl]methyl}acetamideN-[2-(diethylamino)ethyl]-2-{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}-N-{[ 4'-(trifluoromethyl)biphenyl-4-yl]methyl}acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303