5DY4: Crystal structure of human Sirt2 in complex with a brominated 2nd generation SirReal inhibitor and NAD+

PDB ID: 5DY4Download
MMDB ID: 135499
PDB Deposition Date: 2015/9/24
Updated in MMDB: 2016/03
Experimental Method:
x-ray diffraction
Resolution: 1.77  Å
Source Organism:
Similar Structures:
Biological Unit for 5DY4: dimeric; determined by author and by software (PISA)
Molecular Components in 5DY4
Label Count Molecule
Proteins (2 molecules)
2
Nad-dependent Protein Deacetylase Sirtuin-2
(Gene symbol: SIRT2)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
ZINC IONZINC ION
2
2
N-{5-[(7-bromonaphthalen-1-yl)methyl]-1,3-thiazol-2-yl}-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamideN-{5-[(7-bromonaphthalen-1-yl)methyl]-1,3-thiazol-2-yl}-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide
3
2
NICOTINAMIDE-ADENINE-DINUCLEOTIDENICOTINAMIDE-ADENINE-DINUCLEOTIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303