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ERX13311569: Illumina NovaSeq 6000 paired end sequencing
1 ILLUMINA (Illumina NovaSeq 6000) run: 1.9M spots, 578.5M bases, 190.8Mb downloads

Submitted by: EMBL-EBI
Study: A systematic identification of resistance determinants to antisense antibiotics
show Abstracthide Abstract
The rise of antimicrobial resistance (AMR) among human pathogenic microbes is a serious threat to global health, calling for the development of novel treatment strategies. Antibiotics based on programmable antisense oligomers (asobiotics) offer an attractive solution to the “arms-race”, as their specificity can be quickly updated and tailored to target resistant bacteria. In order to understand the genetic architecture of resistance to asobiotics, we employed laboratory evolution assays to identify mutations that decrease susceptibility to antisense peptide nucleic acid (PNA) against four major gram-negative pathogens: Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, and Pseudomonas aeruginosa.
Sample: K. pneumoniae (KFF-acpP), replicate 8
SAMEA116329785 • ERS21378631 • All experiments • All runs
Library:
Name: K08
Instrument: Illumina NovaSeq 6000
Strategy: WGS
Source: GENOMIC
Selection: unspecified
Layout: PAIRED
Runs: 1 run, 1.9M spots, 578.5M bases, 190.8Mb
Run# of Spots# of BasesSizePublished
ERR139097501,915,591578.5M190.8Mb2024-10-29

ID:
35858456

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