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Items: 1 to 20 of 1000

1.

rs1491539956 [Homo sapiens]
    Variant type:
    DELINS
    Alleles:
    TA>- [Show Flanks]
    Chromosome:
    7:24713112 (GRCh38)
    7:24752731 (GRCh37)
    Canonical SPDI:
    NC_000007.14:24713110:ATA:A
    Gene:
    GSDME (Varview)
    Functional Consequence:
    intron_variant
    Validated:
    by frequency,by alfa
    MAF:
    A=0./0 (ALFA)
    -=0.000011/3 (TOPMED)
    HGVS:
    2.

    rs1491520142 [Homo sapiens]
      Variant type:
      INS
      Alleles:
      ->A,ATA,ATATA [Show Flanks]
      Chromosome:
      7:24748169 (GRCh38)
      7:24787789 (GRCh37)
      Canonical SPDI:
      NC_000007.14:24748169::A,NC_000007.14:24748169::ATA,NC_000007.14:24748169::ATATA
      Gene:
      GSDME (Varview)
      Functional Consequence:
      intron_variant
      Validated:
      by frequency,by alfa,by cluster
      MAF:
      ATA=0./0 (ALFA)
      A=0.00421/40 (TOMMO)
      A=0.00629/6 (Korea1K)
      HGVS:
      3.

      rs1491515023 [Homo sapiens]
        Variant type:
        DEL
        Alleles:
        CA>- [Show Flanks]
        Chromosome:
        7:24754485 (GRCh38)
        7:24794104 (GRCh37)
        Canonical SPDI:
        NC_000007.14:24754484:CA:
        Gene:
        GSDME (Varview)
        Functional Consequence:
        intron_variant
        Validated:
        by frequency,by alfa
        MAF:
        -=0./0 (ALFA)
        HGVS:
        4.

        rs1491512388 has merged into rs1386568097 [Homo sapiens]
          Variant type:
          DELINS
          Alleles:
          A>-,AA [Show Flanks]
          Chromosome:
          7:24759877 (GRCh38)
          7:24799496 (GRCh37)
          Canonical SPDI:
          NC_000007.14:24759876:AAAAAAA:AAAAAA,NC_000007.14:24759876:AAAAAAA:AAAAAAAA
          Gene:
          GSDME (Varview), LOC124901820 (Varview)
          Functional Consequence:
          upstream_transcript_variant,genic_upstream_transcript_variant,intron_variant
          Validated:
          by frequency,by alfa,by cluster
          MAF:
          AAAAAA=0.000054/1 (ALFA)
          -=0.000021/3 (GnomAD)
          -=0.000035/1 (TOMMO)
          -=0.000223/1 (Estonian)
          HGVS:
          5.

          rs1491406473 [Homo sapiens]
            Variant type:
            DEL
            Alleles:
            CG>- [Show Flanks]
            Chromosome:
            7:24744984 (GRCh38)
            7:24784603 (GRCh37)
            Canonical SPDI:
            NC_000007.14:24744983:CG:
            Gene:
            GSDME (Varview)
            Functional Consequence:
            intron_variant
            Validated:
            by frequency,by alfa
            MAF:
            -=0./0 (ALFA)
            -=0.00002/1 (GnomAD)
            HGVS:
            6.

            rs1491391710 has merged into rs34712480 [Homo sapiens]
              Variant type:
              DELINS
              Alleles:
              AAAAAA>-,A,AA,AAA,AAAA,AAAAA,AAAAAAA,AAAAAAAA,AAAAAAAAAAAAA,AAAAAAAAAAAAAAAA [Show Flanks]
              Chromosome:
              7:24754497 (GRCh38)
              7:24794116 (GRCh37)
              Canonical SPDI:
              NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAA,NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAAA,NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAAAA,NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAAAAA,NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAAAAAA,NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAAAAAAA,NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAAAAAAAAA,NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAAAAAAAAAA,NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAAAAAAAAAAAAAAA,NC_000007.14:24754485:AAAAAAAAAAAAAAAAA:AAAAAAAAAAAAAAAAAAAAAAAAAAA
              Gene:
              GSDME (Varview)
              Functional Consequence:
              intron_variant
              Validated:
              by frequency,by alfa,by cluster
              MAF:
              AAAAAAAAAAAAA=0./0 (ALFA)
              -=0.1897/731 (ALSPAC)
              -=0.4968/2488 (1000Genomes)
              HGVS:
              NC_000007.14:g.24754497_24754502del, NC_000007.14:g.24754498_24754502del, NC_000007.14:g.24754499_24754502del, NC_000007.14:g.24754500_24754502del, NC_000007.14:g.24754501_24754502del, NC_000007.14:g.24754502del, NC_000007.14:g.24754502dup, NC_000007.14:g.24754501_24754502dup, NC_000007.14:g.24754496_24754502dup, NC_000007.14:g.24754493_24754502dup, NC_000007.13:g.24794116_24794121del, NC_000007.13:g.24794117_24794121del, NC_000007.13:g.24794118_24794121del, NC_000007.13:g.24794119_24794121del, NC_000007.13:g.24794120_24794121del, NC_000007.13:g.24794121del, NC_000007.13:g.24794121dup, NC_000007.13:g.24794120_24794121dup, NC_000007.13:g.24794115_24794121dup, NC_000007.13:g.24794112_24794121dup, NG_011593.1:g.8530_8535del, NG_011593.1:g.8531_8535del, NG_011593.1:g.8532_8535del, NG_011593.1:g.8533_8535del, NG_011593.1:g.8534_8535del, NG_011593.1:g.8535del, NG_011593.1:g.8535dup, NG_011593.1:g.8534_8535dup, NG_011593.1:g.8529_8535dup, NG_011593.1:g.8526_8535dup
              7.

              rs1491331096 [Homo sapiens]
                Variant type:
                DELINS
                Alleles:
                CA>- [Show Flanks]
                Chromosome:
                7:24706409 (GRCh38)
                7:24746028 (GRCh37)
                Canonical SPDI:
                NC_000007.14:24706405:ACACA:ACA
                Gene:
                GSDME (Varview)
                Functional Consequence:
                intron_variant
                Validated:
                by frequency,by alfa,by cluster
                MAF:
                ACA=0.000071/1 (ALFA)
                -=0.000019/5 (TOPMED)
                -=0.000029/4 (GnomAD)
                HGVS:
                8.

                rs1491322566 [Homo sapiens]
                  Variant type:
                  DEL
                  Alleles:
                  TA>- [Show Flanks]
                  Chromosome:
                  7:24759876 (GRCh38)
                  7:24799495 (GRCh37)
                  Canonical SPDI:
                  NC_000007.14:24759875:TA:
                  Gene:
                  GSDME (Varview), LOC124901820 (Varview)
                  Functional Consequence:
                  upstream_transcript_variant,intron_variant,genic_upstream_transcript_variant
                  Validated:
                  by frequency,by alfa,by cluster
                  MAF:
                  -=0./0 (ALFA)
                  -=0.000007/1 (GnomAD)
                  -=0.000019/5 (TOPMED)
                  HGVS:
                  9.

                  rs1491320772 [Homo sapiens]
                    Variant type:
                    SNV:
                    Alleles:
                    TC>-
                    Chromosome:
                    no mapping
                    Canonical SPDI:
                    10.

                    rs1491241831 [Homo sapiens]
                      Variant type:
                      DELINS
                      Alleles:
                      ->GCCTGCTGTGGAGTGAGGCGA [Show Flanks]
                      Chromosome:
                      7:24706796 (GRCh38)
                      7:24746416 (GRCh37)
                      Canonical SPDI:
                      NC_000007.14:24706796:GAGCCTGCTGTGGAGTGAGGCGA:GAGCCTGCTGTGGAGTGAGGCGAGCCTGCTGTGGAGTGAGGCGA
                      Gene:
                      GSDME (Varview)
                      Functional Consequence:
                      intron_variant
                      Validated:
                      by frequency,by alfa
                      MAF:
                      GAGCCTGCTGTGGAGTGAGGCGAGCCTGCTGTGGAGTGAGGCGA=0./0 (ALFA)
                      GAGCCTGCTGTGGAGTGAGGC=0.000004/1 (TOPMED)
                      HGVS:
                      11.

                      rs1491208830 [Homo sapiens]
                        Variant type:
                        DELINS
                        Alleles:
                        ->T [Show Flanks]
                        Chromosome:
                        7:24713111 (GRCh38)
                        7:24752731 (GRCh37)
                        Canonical SPDI:
                        NC_000007.14:24713111:T:TT
                        Gene:
                        GSDME (Varview)
                        Functional Consequence:
                        intron_variant
                        Validated:
                        by frequency,by alfa
                        MAF:
                        TT=0./0 (ALFA)
                        T=0.000019/5 (TOPMED)
                        HGVS:
                        12.

                        rs1491177054 [Homo sapiens]
                          Variant type:
                          DELINS
                          Alleles:
                          CA>- [Show Flanks]
                          Chromosome:
                          7:24705997 (GRCh38)
                          7:24745616 (GRCh37)
                          Canonical SPDI:
                          NC_000007.14:24705994:CACA:CA
                          Gene:
                          GSDME (Varview)
                          Functional Consequence:
                          intron_variant
                          Validated:
                          by frequency,by alfa,by cluster
                          MAF:
                          CACA=0./0 (ALFA)
                          -=0.000008/2 (TOPMED)
                          -=0.000014/2 (GnomAD)
                          HGVS:
                          13.

                          rs1491163377 [Homo sapiens]
                            Variant type:
                            INS
                            Alleles:
                            ->A,AA,AAA [Show Flanks]
                            Chromosome:
                            7:24762248 (GRCh38)
                            7:24801868 (GRCh37)
                            Canonical SPDI:
                            NC_000007.14:24762248::A,NC_000007.14:24762248::AA,NC_000007.14:24762248::AAA
                            Gene:
                            GSDME (Varview), LOC124901820 (Varview)
                            Functional Consequence:
                            intron_variant,genic_upstream_transcript_variant
                            Validated:
                            by frequency,by alfa,by cluster
                            MAF:
                            AA=0./0 (ALFA)
                            AA=0.00024/4 (TOMMO)
                            HGVS:
                            14.

                            rs1491152143 has merged into rs3038357 [Homo sapiens]
                              Variant type:
                              DELINS
                              Alleles:
                              TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG>-,TGTG,TGTGTG,TGTGTGTG,TGTGTGTGTG,TGTGTGTGTGTG,TGTGTGTGTGTGTG,TGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG [Show Flanks]
                              Chromosome:
                              7:24744998 (GRCh38)
                              7:24784617 (GRCh37)
                              Canonical SPDI:
                              NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG,NC_000007.14:24744984:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG:GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
                              Gene:
                              GSDME (Varview)
                              Functional Consequence:
                              intron_variant
                              Clinical significance:
                              benign
                              Validated:
                              by frequency,by alfa,by cluster
                              MAF:
                              GTGTGTGTGTGTGTGTG=0./0 (ALFA)
                              GTGT=0.4615/2311 (1000Genomes)
                              HGVS:
                              NC_000007.14:g.24744986TG[6], NC_000007.14:g.24744986TG[8], NC_000007.14:g.24744986TG[9], NC_000007.14:g.24744986TG[10], NC_000007.14:g.24744986TG[11], NC_000007.14:g.24744986TG[12], NC_000007.14:g.24744986TG[13], NC_000007.14:g.24744986TG[14], NC_000007.14:g.24744986TG[15], NC_000007.14:g.24744986TG[16], NC_000007.14:g.24744986TG[17], NC_000007.14:g.24744986TG[18], NC_000007.14:g.24744986TG[19], NC_000007.14:g.24744986TG[20], NC_000007.14:g.24744986TG[21], NC_000007.14:g.24744986TG[22], NC_000007.14:g.24744986TG[23], NC_000007.14:g.24744986TG[24], NC_000007.14:g.24744986TG[26], NC_000007.14:g.24744986TG[27], NC_000007.14:g.24744986TG[28], NC_000007.14:g.24744986TG[29], NC_000007.14:g.24744986TG[30], NC_000007.14:g.24744986TG[31], NC_000007.14:g.24744986TG[32], NC_000007.14:g.24744986TG[33], NC_000007.14:g.24744986TG[34], NC_000007.13:g.24784605TG[6], NC_000007.13:g.24784605TG[8], NC_000007.13:g.24784605TG[9], NC_000007.13:g.24784605TG[10], NC_000007.13:g.24784605TG[11], NC_000007.13:g.24784605TG[12], NC_000007.13:g.24784605TG[13], NC_000007.13:g.24784605TG[14], NC_000007.13:g.24784605TG[15], NC_000007.13:g.24784605TG[16], NC_000007.13:g.24784605TG[17], NC_000007.13:g.24784605TG[18], NC_000007.13:g.24784605TG[19], NC_000007.13:g.24784605TG[20], NC_000007.13:g.24784605TG[21], NC_000007.13:g.24784605TG[22], NC_000007.13:g.24784605TG[23], NC_000007.13:g.24784605TG[24], NC_000007.13:g.24784605TG[26], NC_000007.13:g.24784605TG[27], NC_000007.13:g.24784605TG[28], NC_000007.13:g.24784605TG[29], NC_000007.13:g.24784605TG[30], NC_000007.13:g.24784605TG[31], NC_000007.13:g.24784605TG[32], NC_000007.13:g.24784605TG[33], NC_000007.13:g.24784605TG[34], NG_011593.1:g.17987AC[6], NG_011593.1:g.17987AC[8], NG_011593.1:g.17987AC[9], NG_011593.1:g.17987AC[10], NG_011593.1:g.17987AC[11], NG_011593.1:g.17987AC[12], NG_011593.1:g.17987AC[13], NG_011593.1:g.17987AC[14], NG_011593.1:g.17987AC[15], NG_011593.1:g.17987AC[16], NG_011593.1:g.17987AC[17], NG_011593.1:g.17987AC[18], NG_011593.1:g.17987AC[19], NG_011593.1:g.17987AC[20], NG_011593.1:g.17987AC[21], NG_011593.1:g.17987AC[22], NG_011593.1:g.17987AC[23], NG_011593.1:g.17987AC[24], NG_011593.1:g.17987AC[26], NG_011593.1:g.17987AC[27], NG_011593.1:g.17987AC[28], NG_011593.1:g.17987AC[29], NG_011593.1:g.17987AC[30], NG_011593.1:g.17987AC[31], NG_011593.1:g.17987AC[32], NG_011593.1:g.17987AC[33], NG_011593.1:g.17987AC[34]
                              15.

                              rs1491114145 has merged into rs1366320411 [Homo sapiens]
                                Variant type:
                                DELINS
                                Alleles:
                                TTT>-,T,TT,TTTT,TTTTT,TTTTTT,TTTTTTT,TTTTTTTT,TTTTTTTTT,TTTTTTTTTT,TTTTTTTTTTT,TTTTTTTTTTTT [Show Flanks]
                                Chromosome:
                                7:24748175 (GRCh38)
                                7:24787794 (GRCh37)
                                Canonical SPDI:
                                NC_000007.14:24748168:TTTTTTTTT:TTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTTTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTTTTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTTTTTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTTTTTTTTTTT,NC_000007.14:24748168:TTTTTTTTT:TTTTTTTTTTTTTTTTTT
                                Gene:
                                GSDME (Varview)
                                Functional Consequence:
                                intron_variant
                                Validated:
                                by frequency,by alfa,by cluster
                                MAF:
                                TTTTTTT=0./0 (ALFA)
                                HGVS:
                                NC_000007.14:g.24748175_24748177del, NC_000007.14:g.24748176_24748177del, NC_000007.14:g.24748177del, NC_000007.14:g.24748177dup, NC_000007.14:g.24748176_24748177dup, NC_000007.14:g.24748175_24748177dup, NC_000007.14:g.24748174_24748177dup, NC_000007.14:g.24748173_24748177dup, NC_000007.14:g.24748172_24748177dup, NC_000007.14:g.24748171_24748177dup, NC_000007.14:g.24748170_24748177dup, NC_000007.14:g.24748169_24748177dup, NC_000007.13:g.24787794_24787796del, NC_000007.13:g.24787795_24787796del, NC_000007.13:g.24787796del, NC_000007.13:g.24787796dup, NC_000007.13:g.24787795_24787796dup, NC_000007.13:g.24787794_24787796dup, NC_000007.13:g.24787793_24787796dup, NC_000007.13:g.24787792_24787796dup, NC_000007.13:g.24787791_24787796dup, NC_000007.13:g.24787790_24787796dup, NC_000007.13:g.24787789_24787796dup, NC_000007.13:g.24787788_24787796dup, NG_011593.1:g.14850_14852del, NG_011593.1:g.14851_14852del, NG_011593.1:g.14852del, NG_011593.1:g.14852dup, NG_011593.1:g.14851_14852dup, NG_011593.1:g.14850_14852dup, NG_011593.1:g.14849_14852dup, NG_011593.1:g.14848_14852dup, NG_011593.1:g.14847_14852dup, NG_011593.1:g.14846_14852dup, NG_011593.1:g.14845_14852dup, NG_011593.1:g.14844_14852dup
                                16.

                                rs1491097067 [Homo sapiens]
                                  Variant type:
                                  DELINS
                                  Alleles:
                                  ->TTC [Show Flanks]
                                  Chromosome:
                                  7:24697673 (GRCh38)
                                  7:24737293 (GRCh37)
                                  Canonical SPDI:
                                  NC_000007.14:24697673:TTC:TTCTTC
                                  Validated:
                                  by frequency,by alfa
                                  MAF:
                                  TTCTTC=0./0 (ALFA)
                                  TTC=0.000008/2 (TOPMED)
                                  HGVS:
                                  17.

                                  rs1491021717 has merged into rs141820646 [Homo sapiens]
                                    Variant type:
                                    DELINS
                                    Alleles:
                                    AAAAAA>-,A,AA,AAA,AAAA,AAAAA,AAAAAAA,AAAAAAAA,AAAAAAAAA,AAAAAAAAAA,AAAAAAAAAAAAAAAA [Show Flanks]
                                    Chromosome:
                                    7:24724183 (GRCh38)
                                    7:24763802 (GRCh37)
                                    Canonical SPDI:
                                    NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAAAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAAAAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAAAAAAAAAAA,NC_000007.14:24724174:AAAAAAAAAAAAAA:AAAAAAAAAAAAAAAAAAAAAAAA
                                    Gene:
                                    GSDME (Varview)
                                    Functional Consequence:
                                    intron_variant
                                    Validated:
                                    by frequency,by alfa,by cluster
                                    MAF:
                                    AAAAAAAAA=0./0 (ALFA)
                                    -=0.000008/2 (TOPMED)
                                    AA=0.163161/605 (TWINSUK)
                                    AA=0.167099/644 (ALSPAC)
                                    AA=0.244209/1223 (1000Genomes)
                                    HGVS:
                                    NC_000007.14:g.24724183_24724188del, NC_000007.14:g.24724184_24724188del, NC_000007.14:g.24724185_24724188del, NC_000007.14:g.24724186_24724188del, NC_000007.14:g.24724187_24724188del, NC_000007.14:g.24724188del, NC_000007.14:g.24724188dup, NC_000007.14:g.24724187_24724188dup, NC_000007.14:g.24724186_24724188dup, NC_000007.14:g.24724185_24724188dup, NC_000007.14:g.24724179_24724188dup, NC_000007.13:g.24763802_24763807del, NC_000007.13:g.24763803_24763807del, NC_000007.13:g.24763804_24763807del, NC_000007.13:g.24763805_24763807del, NC_000007.13:g.24763806_24763807del, NC_000007.13:g.24763807del, NC_000007.13:g.24763807dup, NC_000007.13:g.24763806_24763807dup, NC_000007.13:g.24763805_24763807dup, NC_000007.13:g.24763804_24763807dup, NC_000007.13:g.24763798_24763807dup, NG_011593.1:g.38841_38846del, NG_011593.1:g.38842_38846del, NG_011593.1:g.38843_38846del, NG_011593.1:g.38844_38846del, NG_011593.1:g.38845_38846del, NG_011593.1:g.38846del, NG_011593.1:g.38846dup, NG_011593.1:g.38845_38846dup, NG_011593.1:g.38844_38846dup, NG_011593.1:g.38843_38846dup, NG_011593.1:g.38837_38846dup
                                    18.

                                    rs1490980295 [Homo sapiens]
                                      Variant type:
                                      DELINS
                                      Alleles:
                                      CAAA>- [Show Flanks]
                                      Chromosome:
                                      7:24753504 (GRCh38)
                                      7:24793123 (GRCh37)
                                      Canonical SPDI:
                                      NC_000007.14:24753496:AAACAAACAAA:AAACAAA
                                      Gene:
                                      GSDME (Varview)
                                      Functional Consequence:
                                      intron_variant
                                      Validated:
                                      by frequency,by alfa,by cluster
                                      MAF:
                                      AAACAAA=0./0 (ALFA)
                                      -=0.000023/6 (TOPMED)
                                      -=0.000057/8 (GnomAD)
                                      HGVS:
                                      19.

                                      rs1490941312 [Homo sapiens]
                                        Variant type:
                                        SNV
                                        Alleles:
                                        A>G [Show Flanks]
                                        Chromosome:
                                        7:24696754 (GRCh38)
                                        7:24736373 (GRCh37)
                                        Canonical SPDI:
                                        NC_000007.14:24696753:A:G
                                        Validated:
                                        by frequency,by alfa,by cluster
                                        MAF:
                                        G=0./0 (ALFA)
                                        G=0.000004/1 (TOPMED)
                                        G=0.000016/2 (GnomAD)
                                        HGVS:
                                        20.

                                        rs1490921433 [Homo sapiens]
                                          Variant type:
                                          SNV
                                          Alleles:
                                          C>T [Show Flanks]
                                          Chromosome:
                                          7:24703493 (GRCh38)
                                          7:24743112 (GRCh37)
                                          Canonical SPDI:
                                          NC_000007.14:24703492:C:T
                                          Gene:
                                          GSDME (Varview)
                                          Functional Consequence:
                                          intron_variant
                                          Validated:
                                          by frequency,by alfa
                                          MAF:
                                          T=0./0 (ALFA)
                                          T=0.000004/1 (TOPMED)
                                          HGVS:

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