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    Wdr47 WD repeat domain 47 [ Mus musculus (house mouse) ]

    Gene ID: 99512, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr47provided by MGI
    Official Full Name
    WD repeat domain 47provided by MGI
    Primary source
    MGI:MGI:2139593
    See related
    Ensembl:ENSMUSG00000040389 AllianceGenome:MGI:2139593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0893; 1810073M12Rik
    Summary
    Acts upstream of or within several processes, including detection of hot stimulus involved in thermoception; neuronal stem cell population maintenance; and telencephalon development. Located in several cellular components, including growth cone; microtubule; and neuronal cell body. Is expressed in several structures, including central nervous system; pancreas; respiratory system; sensory organ; and vibrissa. Orthologous to human WDR47 (WD repeat domain 47). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 32.5), CNS E14 (RPKM 23.3) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wdr47 in Genome Data Viewer
    Location:
    3 F3; 3 47.38 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108498302..108553035)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108591223..108645719)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:108365309-108365496 Neighboring gene STARR-positive B cell enhancer ABC_E3459 Neighboring gene transmembrane protein 167B Neighboring gene STARR-positive B cell enhancer ABC_E1629 Neighboring gene STARR-positive B cell enhancer ABC_E6105 Neighboring gene TATA-box binding protein associated factor 13 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene chloride channel CLIC-like 1 Neighboring gene G-protein signalling modulator 2 (AGS3-like, C. elegans) Neighboring gene STARR-positive B cell enhancer ABC_E4575 Neighboring gene AKNA domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anterior commissure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex radial glia-guided migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within detection of hot stimulus involved in thermoception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within motor behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 47
    Names
    nemitin
    neuronal enriched MAP interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358053.1NP_001344982.1  WD repeat-containing protein 47 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683823
      Conserved Domains (4) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      cd00200
      Location:599915
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:611659
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    2. NM_001358054.1NP_001344983.1  WD repeat-containing protein 47 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL683823
      Conserved Domains (5) summary
      smart00667
      Location:942
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      cd00200
      Location:600868
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:612660
      7WD40; WD40 repeat [structural motif]
      cl26927
      Location:293483
      Activator_LAG-3; Transcriptional activator LAG-3
    3. NM_001358055.1NP_001344984.1  WD repeat-containing protein 47 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL683823
      Conserved Domains (5) summary
      smart00667
      Location:942
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      cd00200
      Location:600868
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:612660
      7WD40; WD40 repeat [structural motif]
      cl26927
      Location:293483
      Activator_LAG-3; Transcriptional activator LAG-3
    4. NM_181400.3NP_852065.2  WD repeat-containing protein 47 isoform 1

      See identical proteins and their annotated locations for NP_852065.2

      Status: VALIDATED

      Source sequence(s)
      AL683823
      Consensus CDS
      CCDS17765.1
      UniProtKB/Swiss-Prot
      A2AGC7, Q80TP4, Q8CGF6
      Related
      ENSMUSP00000057482.9, ENSMUST00000051145.15
      Conserved Domains (5) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:293483
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:600916
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:612660
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      108498302..108553035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502415.5XP_006502478.1  WD repeat-containing protein 47 isoform X9

      See identical proteins and their annotated locations for XP_006502478.1

      Conserved Domains (5) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:300490
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:607925
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:619667
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    2. XM_006502414.5XP_006502477.1  WD repeat-containing protein 47 isoform X9

      See identical proteins and their annotated locations for XP_006502477.1

      Conserved Domains (5) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:300490
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:607925
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:619667
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    3. XM_036163436.1XP_036019329.1  WD repeat-containing protein 47 isoform X10

      Conserved Domains (4) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      cd00200
      Location:607923
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:619667
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    4. XM_006502417.5XP_006502480.1  WD repeat-containing protein 47 isoform X11

      Conserved Domains (5) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:293483
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:600918
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:612660
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    5. XM_011240310.3XP_011238612.1  WD repeat-containing protein 47 isoform X12

      Conserved Domains (5) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:293482
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:599917
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:611659
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    6. XM_017319818.3XP_017175307.1  WD repeat-containing protein 47 isoform X9

      Conserved Domains (5) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:300490
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:607925
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:619667
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    7. XM_011240309.3XP_011238611.1  WD repeat-containing protein 47 isoform X10

      Conserved Domains (4) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      cd00200
      Location:607923
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:619667
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    8. XM_030252938.2XP_030108798.1  WD repeat-containing protein 47 isoform X11

      Conserved Domains (5) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:293483
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:600918
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:612660
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    9. XM_017319819.2XP_017175308.1  WD repeat-containing protein 47 isoform X13

      UniProtKB/Swiss-Prot
      A2AGC7, Q80TP4, Q8CGF6
      Conserved Domains (5) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:293483
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:600916
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:612660
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    10. XM_036163437.1XP_036019330.1  WD repeat-containing protein 47 isoform X14

      Conserved Domains (4) summary
      smart00668
      Location:45102
      CTLH; C-terminal to LisH motif
      cd00200
      Location:599915
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:611659
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:1340
      LisH_TPL; LisH-like dimerisation domain
    11. XM_030252937.2XP_030108797.1  WD repeat-containing protein 47 isoform X8

      Conserved Domains (5) summary
      smart00668
      Location:95152
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:343532
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:649965
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:661709
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:6390
      LisH_TPL; LisH-like dimerisation domain
    12. XM_030252939.2XP_030108799.1  WD repeat-containing protein 47 isoform X15

      Conserved Domains (5) summary
      smart00668
      Location:95152
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:350540
      Activator_LAG-3; Transcriptional activator LAG-3
      sd00039
      Location:668715
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:6390
      LisH_TPL; LisH-like dimerisation domain
      cl29593
      Location:657756
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    13. XM_030252932.1XP_030108792.1  WD repeat-containing protein 47 isoform X1

      Conserved Domains (5) summary
      smart00668
      Location:95152
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:350540
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:657975
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:669717
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:6390
      LisH_TPL; LisH-like dimerisation domain
    14. XM_030252933.2XP_030108793.1  WD repeat-containing protein 47 isoform X3

      Conserved Domains (5) summary
      smart00668
      Location:95152
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:350540
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:657973
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:669717
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:6390
      LisH_TPL; LisH-like dimerisation domain
    15. XM_011240308.2XP_011238610.2  WD repeat-containing protein 47 isoform X2

      Conserved Domains (5) summary
      smart00668
      Location:95152
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:350539
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:656974
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:668716
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:6390
      LisH_TPL; LisH-like dimerisation domain
    16. XM_036163435.1XP_036019328.1  WD repeat-containing protein 47 isoform X4

      Conserved Domains (4) summary
      smart00668
      Location:95152
      CTLH; C-terminal to LisH motif
      cd00200
      Location:656972
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:668716
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:6390
      LisH_TPL; LisH-like dimerisation domain
    17. XM_030252934.1XP_030108794.1  WD repeat-containing protein 47 isoform X5

      Conserved Domains (5) summary
      smart00668
      Location:95152
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:343533
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:650968
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:662710
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:6390
      LisH_TPL; LisH-like dimerisation domain
    18. XM_030252936.2XP_030108796.1  WD repeat-containing protein 47 isoform X7

      Conserved Domains (5) summary
      smart00668
      Location:95152
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:343533
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:650966
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:662710
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:6390
      LisH_TPL; LisH-like dimerisation domain
    19. XM_030252935.1XP_030108795.1  WD repeat-containing protein 47 isoform X6

      Conserved Domains (5) summary
      smart00668
      Location:95152
      CTLH; C-terminal to LisH motif
      pfam11498
      Location:343532
      Activator_LAG-3; Transcriptional activator LAG-3
      cd00200
      Location:649967
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:661709
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:6390
      LisH_TPL; LisH-like dimerisation domain

    RNA

    1. XR_004941418.1 RNA Sequence