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    TBC1D5 TBC1 domain family member 5 [ Homo sapiens (human) ]

    Gene ID: 9779, updated on 9-Dec-2024

    Summary

    Official Symbol
    TBC1D5provided by HGNC
    Official Full Name
    TBC1 domain family member 5provided by HGNC
    Primary source
    HGNC:HGNC:19166
    See related
    Ensembl:ENSG00000131374 MIM:615740; AllianceGenome:HGNC:19166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in several cellular components, including Atg1/ULK1 kinase complex; autophagosome; and cytoplasmic vesicle membrane. Part of retromer complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.6), brain (RPKM 10.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TBC1D5 in Genome Data Viewer
    Location:
    3p24.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (17157162..17742631, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (17159342..17744665, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (17198654..17784123, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phospholipase C like 2 Neighboring gene microRNA 3714 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:17041383-17041908 Neighboring gene Sharpr-MPRA regulatory region 1410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19561 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:17080505-17081704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19562 Neighboring gene PLCL2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19563 Neighboring gene Sharpr-MPRA regulatory region 1226 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_66731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:17192997-17193498 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:17194853-17195024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:17199910-17200410 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:17200411-17200911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:17211116-17211616 Neighboring gene NANOG hESC enhancer GRCh37_chr3:17217563-17218064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19568 Neighboring gene Sharpr-MPRA regulatory region 10783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19570 Neighboring gene MPRA-validated peak4551 silencer Neighboring gene RBIS pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 9690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:17535720-17536296 Neighboring gene ribosomal protein L31 pseudogene 19 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:17588257-17589120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19571 Neighboring gene MPRA-validated peak4555 silencer Neighboring gene MPRA-validated peak4556 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:17734513-17735014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:17735015-17735514 Neighboring gene tRNA-Cys (anticodon GCA) 25-1 Neighboring gene RNA, U7 small nuclear 10 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14125 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:17783809-17784512 Neighboring gene uncharacterized LOC105376975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14127 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14128 Neighboring gene uncharacterized LOC124909350

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2015-10-30)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2015-10-30)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0210

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables retromer complex binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Atg1/ULK1 kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of retromer complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    TBC1 domain family member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134381.2NP_001127853.1  TBC1 domain family member 5 isoform a

      See identical proteins and their annotated locations for NP_001127853.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 3, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AC090644, AK310539, BM976960
      Consensus CDS
      CCDS46770.1
      Related
      ENSP00000402935.2, ENST00000446818.6
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    2. NM_001349073.2NP_001336002.1  TBC1 domain family member 5 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1, 4, and 5, encodes isoform a.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Consensus CDS
      CCDS46770.1
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    3. NM_001349074.2NP_001336003.1  TBC1 domain family member 5 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 3, and 5, encodes isoform a.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Consensus CDS
      CCDS46770.1
      Related
      ENSP00000512418.1, ENST00000696125.1
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    4. NM_001349075.2NP_001336004.1  TBC1 domain family member 5 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 3, and 4, encodes isoform a.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Consensus CDS
      CCDS46770.1
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    5. NM_001349076.2NP_001336005.1  TBC1 domain family member 5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 2, 7, 8, 9, and 10, encodes isoform b.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Consensus CDS
      CCDS33714.1
      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    6. NM_001349077.2NP_001336006.1  TBC1 domain family member 5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 2, 6, 8, 9, and 10, encodes isoform b.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Consensus CDS
      CCDS33714.1
      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
      Related
      ENSP00000398127.4, ENST00000429383.8
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    7. NM_001349078.2NP_001336007.1  TBC1 domain family member 5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 2, 6, 7, 9, and 10, encodes isoform b.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Consensus CDS
      CCDS33714.1
      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    8. NM_001349079.2NP_001336008.1  TBC1 domain family member 5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 2, 6, 7, 8, and 10, encodes isoform b.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Consensus CDS
      CCDS33714.1
      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    9. NM_001349080.2NP_001336009.1  TBC1 domain family member 5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 2, 6, 7, 8, and 9, encodes isoform b.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Consensus CDS
      CCDS33714.1
      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    10. NM_001349081.2NP_001336010.1  TBC1 domain family member 5 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) encodes isoform c.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC140076, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:86388
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    11. NM_001349082.2NP_001336011.1  TBC1 domain family member 5 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 13, 14, 15, and 16, encodes isoform d.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    12. NM_001349083.2NP_001336012.1  TBC1 domain family member 5 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 12, 14, 15, and 16, encodes isoform d.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    13. NM_001349084.2NP_001336013.1  TBC1 domain family member 5 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 12, 13, 15, and 16, encodes isoform d.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    14. NM_001349085.2NP_001336014.1  TBC1 domain family member 5 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 12, 13, 14, and 16, encodes isoform d.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC140076, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    15. NM_001349086.2NP_001336015.1  TBC1 domain family member 5 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 12, 13, 14, and 15, encodes isoform d.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    16. NM_001349087.2NP_001336016.1  TBC1 domain family member 5 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 18, 19, 20, and 21, encodes isoform e.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    17. NM_001349088.2NP_001336017.1  TBC1 domain family member 5 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 17, 19, 20, and 21, encodes isoform e.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    18. NM_001349089.2NP_001336018.1  TBC1 domain family member 5 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variants 17, 18, 20, and 21, encodes isoform e.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    19. NM_001349090.2NP_001336019.1  TBC1 domain family member 5 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variants 17, 18, 19, and 21, encodes isoform e.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    20. NM_001349091.2NP_001336020.1  TBC1 domain family member 5 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variants 17, 18, 19, and 20, encodes isoform e.
      Source sequence(s)
      AC090644, AC090960, AC104451, AC144531
      Conserved Domains (1) summary
      smart00164
      Location:19245
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    21. NM_014744.2NP_055559.1  TBC1 domain family member 5 isoform b

      See identical proteins and their annotated locations for NP_055559.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 6, 7, 8, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      AC090644, AC104451, BM976960, D86965
      Consensus CDS
      CCDS33714.1
      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
      Related
      ENSP00000253692.6, ENST00000253692.11
      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      17157162..17742631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449296.1XP_047305252.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    2. XM_011534283.4XP_011532585.1  TBC1 domain family member 5 isoform X1

      See identical proteins and their annotated locations for XP_011532585.1

      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    3. XM_047449314.1XP_047305270.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    4. XM_047449291.1XP_047305247.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    5. XM_047449286.1XP_047305242.1  TBC1 domain family member 5 isoform X1

    6. XM_047449301.1XP_047305257.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    7. XM_017007556.2XP_016863045.1  TBC1 domain family member 5 isoform X1

      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    8. XM_047449303.1XP_047305259.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    9. XM_017007555.3XP_016863044.1  TBC1 domain family member 5 isoform X1

      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    10. XM_047449299.1XP_047305255.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    11. XM_047449288.1XP_047305244.1  TBC1 domain family member 5 isoform X1

    12. XM_047449297.1XP_047305253.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    13. XM_047449285.1XP_047305241.1  TBC1 domain family member 5 isoform X1

    14. XM_047449293.1XP_047305249.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    15. XM_011534284.3XP_011532586.1  TBC1 domain family member 5 isoform X1

      See identical proteins and their annotated locations for XP_011532586.1

      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    16. XM_047449294.1XP_047305250.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    17. XM_047449290.1XP_047305246.1  TBC1 domain family member 5 isoform X1

    18. XM_047449308.1XP_047305264.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    19. XM_047449317.1XP_047305273.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    20. XM_047449287.1XP_047305243.1  TBC1 domain family member 5 isoform X1

    21. XM_047449302.1XP_047305258.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    22. XM_047449298.1XP_047305254.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    23. XM_011534281.2XP_011532583.1  TBC1 domain family member 5 isoform X1

      See identical proteins and their annotated locations for XP_011532583.1

      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    24. XM_047449295.1XP_047305251.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    25. XM_047449292.1XP_047305248.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    26. XM_017007553.3XP_016863042.1  TBC1 domain family member 5 isoform X1

      Conserved Domains (1) summary
      smart00164
      Location:79381
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    27. XM_047449304.1XP_047305260.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    28. XM_047449284.1XP_047305240.1  TBC1 domain family member 5 isoform X1

    29. XM_047449315.1XP_047305271.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    30. XM_047449311.1XP_047305267.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    31. XM_047449309.1XP_047305265.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    32. XM_047449310.1XP_047305266.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    33. XM_047449318.1XP_047305274.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    34. XM_047449312.1XP_047305268.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    35. XM_047449289.1XP_047305245.1  TBC1 domain family member 5 isoform X1

    36. XM_047449319.1XP_047305275.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    37. XM_047449306.1XP_047305262.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    38. XM_047449316.1XP_047305272.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    39. XM_047449305.1XP_047305261.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    40. XM_047449313.1XP_047305269.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    41. XM_047449300.1XP_047305256.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    42. XM_047449322.1XP_047305278.1  TBC1 domain family member 5 isoform X3

    43. XM_047449320.1XP_047305276.1  TBC1 domain family member 5 isoform X3

    44. XM_047449321.1XP_047305277.1  TBC1 domain family member 5 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      17159342..17744665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348556.1XP_054204531.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    2. XM_054348542.1XP_054204517.1  TBC1 domain family member 5 isoform X1

    3. XM_054348573.1XP_054204548.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    4. XM_054348551.1XP_054204526.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    5. XM_054348544.1XP_054204519.1  TBC1 domain family member 5 isoform X1

    6. XM_054348561.1XP_054204536.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    7. XM_054348540.1XP_054204515.1  TBC1 domain family member 5 isoform X1

    8. XM_054348563.1XP_054204538.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    9. XM_054348547.1XP_054204522.1  TBC1 domain family member 5 isoform X1

    10. XM_054348559.1XP_054204534.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    11. XM_054348548.1XP_054204523.1  TBC1 domain family member 5 isoform X1

    12. XM_054348557.1XP_054204532.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    13. XM_054348543.1XP_054204518.1  TBC1 domain family member 5 isoform X1

    14. XM_054348553.1XP_054204528.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    15. XM_054348539.1XP_054204514.1  TBC1 domain family member 5 isoform X1

    16. XM_054348554.1XP_054204529.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    17. XM_054348550.1XP_054204525.1  TBC1 domain family member 5 isoform X1

    18. XM_054348567.1XP_054204542.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    19. XM_054348576.1XP_054204551.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    20. XM_054348546.1XP_054204521.1  TBC1 domain family member 5 isoform X1

    21. XM_054348562.1XP_054204537.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    22. XM_054348558.1XP_054204533.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    23. XM_054348545.1XP_054204520.1  TBC1 domain family member 5 isoform X1

    24. XM_054348555.1XP_054204530.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    25. XM_054348552.1XP_054204527.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    26. XM_054348538.1XP_054204513.1  TBC1 domain family member 5 isoform X1

    27. XM_054348564.1XP_054204539.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    28. XM_054348541.1XP_054204516.1  TBC1 domain family member 5 isoform X1

    29. XM_054348574.1XP_054204549.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    30. XM_054348570.1XP_054204545.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    31. XM_054348568.1XP_054204543.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    32. XM_054348569.1XP_054204544.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    33. XM_054348577.1XP_054204552.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    34. XM_054348571.1XP_054204546.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    35. XM_054348549.1XP_054204524.1  TBC1 domain family member 5 isoform X1

    36. XM_054348578.1XP_054204553.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    37. XM_054348566.1XP_054204541.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    38. XM_054348575.1XP_054204550.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    39. XM_054348565.1XP_054204540.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    40. XM_054348572.1XP_054204547.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    41. XM_054348560.1XP_054204535.1  TBC1 domain family member 5 isoform X2

      UniProtKB/Swiss-Prot
      A6NP25, C9JP52, Q92609
      UniProtKB/TrEMBL
      B9A6K1
    42. XM_054348581.1XP_054204556.1  TBC1 domain family member 5 isoform X3

    43. XM_054348579.1XP_054204554.1  TBC1 domain family member 5 isoform X3

    44. XM_054348580.1XP_054204555.1  TBC1 domain family member 5 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134380.1: Suppressed sequence

      Description
      NM_001134380.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.