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    CHST10 carbohydrate sulfotransferase 10 [ Homo sapiens (human) ]

    Gene ID: 9486, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CHST10provided by HGNC
    Official Full Name
    carbohydrate sulfotransferase 10provided by HGNC
    Primary source
    HGNC:HGNC:19650
    See related
    Ensembl:ENSG00000115526 MIM:606376; AllianceGenome:HGNC:19650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNK1ST; HNK-1ST
    Summary
    This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
    Expression
    Broad expression in brain (RPKM 10.4), endometrium (RPKM 4.2) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CHST10 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (100391860..100417668, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (100850699..100876504, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101008322..101034130, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11813 Neighboring gene LON peptidase N-terminal domain and ring finger 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:100907393-100908033 Neighboring gene CYCS pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101007732-101008232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101008233-101008733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101021577-101022078 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:101028413-101028940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11815 Neighboring gene RALBP1 pseudogene 2 Neighboring gene uncharacterized LOC105373506 Neighboring gene neuromedin S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. HNK-1 sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan. Sheikh MO, et al. Glycobiology, 2020 Sep 28. PMID 32149355, Free PMC Article
    2. Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids. Ong E, et al. J Biol Chem, 1998 Feb 27. PMID 9478973
    3. Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis. Ong E, et al. J Biol Chem, 1999 Sep 3. PMID 10464296
    4. Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. Zhao X, et al. Cancer Res, 2009 Jun 15. PMID 19470764
    5. Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin. Nakagawa N, et al. Biochem Biophys Res Commun, 2011 Nov 11. PMID 22020094

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. novel role for HNK-1ST as a tumor suppressor controlling the functional glycans on alpha-DG and the importance of sulfate transfer in the glycosylation of alpha-DG.
      Title: Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on α-dystroglycan.
    2. These results suggest that HNK-1ST is involved in 3-O-sulfation of the terminal GlcA of the linkage tetrasaccharide which acts as an inhibitory signal for the initiation of chondroitin sulfate chain biosynthesis on thrombomodulin.
      Title: Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin.
    3. HNK-1ST may be responsible for regulating the sorting of alpha- and beta-TM.
      Title: Involvement of human natural killer-1 (HNK-1) sulfotransferase in the biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl tetrasaccharide found in α-thrombomodulin from human urine.
    4. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.
    5. We show that CHST10 is also regulated by RARgamma in a significant subset of human melanoma cells, and three-dimensional cell culture migration assays suggest that CHST10 functions as a suppressor of invasiveness, but not proliferation, in these cells
      Title: Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10.
    6. identification of a novel member of HNK-1 family of sulfotransferases
      Title: Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC17148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables HNK-1 sulfotransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in androgen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 10
    Names
    HNK-1 sulfotransferase
    huHNK-1ST
    NP_004845.1
    XP_011510509.1
    XP_011510510.1
    XP_011510512.1
    XP_011510513.1
    XP_016860869.1
    XP_016860870.1
    XP_016860871.1
    XP_016860872.1
    XP_024309016.1
    XP_047302389.1
    XP_047302390.1
    XP_047302392.1
    XP_047302393.1
    XP_047302394.1
    XP_054200619.1
    XP_054200620.1
    XP_054200621.1
    XP_054200622.1
    XP_054200623.1
    XP_054200624.1
    XP_054200625.1
    XP_054200626.1
    XP_054200627.1
    XP_054200628.1
    XP_054200629.1
    XP_054200630.1
    XP_054200631.1
    XP_054200632.1
    XP_054200633.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028153.1 RefSeqGene

      Range
      5001..30809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004854.5 → NP_004845.1  carbohydrate sulfotransferase 10

      See identical proteins and their annotated locations for NP_004845.1

      Status: REVIEWED

      Source sequence(s)
      AF033827, AF070594, DA522916, DA732392
      Consensus CDS
      CCDS2047.1
      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Related
      ENSP00000264249.3, ENST00000264249.8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      100391860..100417668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512210.2 → XP_011510512.1  carbohydrate sulfotransferase 10 isoform X1

      See identical proteins and their annotated locations for XP_011510512.1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    2. XM_017005381.3 → XP_016860870.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    3. XM_017005380.3 → XP_016860869.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    4. XM_047446433.1 → XP_047302389.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    5. XM_011512207.3 → XP_011510509.1  carbohydrate sulfotransferase 10 isoform X1

      See identical proteins and their annotated locations for XP_011510509.1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    6. XM_011512208.2 → XP_011510510.1  carbohydrate sulfotransferase 10 isoform X1

      See identical proteins and their annotated locations for XP_011510510.1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    7. XM_011512211.2 → XP_011510513.1  carbohydrate sulfotransferase 10 isoform X1

      See identical proteins and their annotated locations for XP_011510513.1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    8. XM_047446437.1 → XP_047302393.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    9. XM_024453248.2 → XP_024309016.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    10. XM_047446438.1 → XP_047302394.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    11. XM_017005383.3 → XP_016860872.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    12. XM_047446434.1 → XP_047302390.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      Related
      ENSP00000387309.1, ENST00000409701.5

    13. XM_017005382.3 → XP_016860871.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
      UniProtKB/TrEMBL
      B7Z4E8
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    14. XM_047446436.1 → XP_047302392.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      100850699..100876504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344646.1 → XP_054200621.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    2. XM_054344647.1 → XP_054200622.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    3. XM_054344652.1 → XP_054200627.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    4. XM_054344645.1 → XP_054200620.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    5. XM_054344644.1 → XP_054200619.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    6. XM_054344650.1 → XP_054200625.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    7. XM_054344648.1 → XP_054200623.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    8. XM_054344654.1 → XP_054200629.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    9. XM_054344651.1 → XP_054200626.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    10. XM_054344656.1 → XP_054200631.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    11. XM_054344657.1 → XP_054200632.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    12. XM_054344649.1 → XP_054200624.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    13. XM_054344655.1 → XP_054200630.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    14. XM_054344653.1 → XP_054200628.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18

    15. XM_054344658.1 → XP_054200633.1  carbohydrate sulfotransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      O43529, Q53T18
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43529.1 GenPept UniProtKB/Swiss-Prot:O43529

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