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    SLFN11 schlafen family member 11 [ Homo sapiens (human) ]

    Gene ID: 91607, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SLFN11provided by HGNC
    Official Full Name
    schlafen family member 11provided by HGNC
    Primary source
    HGNC:HGNC:26633
    See related
    Ensembl:ENSG00000172716 MIM:614953; AllianceGenome:HGNC:26633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLFN8/9
    Summary
    Enables ATP hydrolysis activity and tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung (RPKM 14.8), thyroid (RPKM 12.0) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SLFN11 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35350305..35373621, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36298255..36321577, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33677324..33700640, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371932 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:33570506-33571134 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:33583732-33584931 Neighboring gene schlafen family member 5 Neighboring gene NANOG hESC enhancer GRCh37_chr17:33638706-33639207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33640386-33641045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:33641707-33642365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660479-33660980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660981-33661480 Neighboring gene RING-box protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12063 Neighboring gene uncharacterized LOC105371933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12066 Neighboring gene UFM1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33720941-33721442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33721443-33721942 Neighboring gene DTW domain containing 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway. Zhou C, et al. Theranostics, 2020. PMID 32292519, Free PMC Article
    2. SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells. Okamoto Y, et al. Blood, 2021 Jan 21. PMID 32735670, Free PMC Article
    3. Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development. Moribe F, et al. PLoS One, 2021. PMID 33513156, Free PMC Article
    4. SLFN11 Expression in Advanced Prostate Cancer and Response to Platinum-based Chemotherapy. Conteduca V, et al. Mol Cancer Ther, 2020 May. PMID 32127465, Free PMC Article
    5. Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers. Takashima T, et al. Br J Cancer, 2021 Jul. PMID 33785877, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.
      Title: Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.
    2. SLFN11 promotes clear cell renal cell carcinoma progression via the PI3K/AKT signaling pathway.
      Title: SLFN11 promotes clear cell renal cell carcinoma progression via the PI3K/AKT signaling pathway.
    3. Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
      Title: Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
    4. SLFN11 negatively regulates non-canonical NFkB signaling to promote glioblastoma progression.
      Title: SLFN11 negatively regulates non-canonical NFkB signaling to promote glioblastoma progression.
    5. Mechanistic understanding of human SLFN11.
      Title: Mechanistic understanding of human SLFN11.
    6. Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer.
      Title: Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer.
    7. FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11.
      Title: FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11.
    8. SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents.
      Title: SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents.
    9. SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer.
      Title: SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer.
    10. Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex.
      Title: Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ34922

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    schlafen family member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104587.2 → NP_001098057.1  schlafen family member 11

      See identical proteins and their annotated locations for NP_001098057.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All 16 variants encode the same protein.
      Source sequence(s)
      AC060766, AK092241, BC052586, BM996330, BP245452, BX490030
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    2. NM_001104588.2 → NP_001098058.1  schlafen family member 11

      See identical proteins and their annotated locations for NP_001098058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 16 variants encode the same protein.
      Source sequence(s)
      AC060766, BC052586, BM996330, BP245452
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    3. NM_001104589.2 → NP_001098059.1  schlafen family member 11

      See identical proteins and their annotated locations for NP_001098059.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All 16 variants encode the same protein.
      Source sequence(s)
      AC060766, BC052586, BM996330, BP245452, CB265500
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    4. NM_001104590.2 → NP_001098060.1  schlafen family member 11

      See identical proteins and their annotated locations for NP_001098060.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All 16 variants encode the same protein.
      Source sequence(s)
      AC060766, AK092241, BC052586, BM996330, BP245452
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Related
      ENSP00000378067.1, ENST00000394566.5
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    5. NM_001376007.1 → NP_001362936.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Related
      ENSP00000510787.1, ENST00000685675.1
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    6. NM_001376008.1 → NP_001362937.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    7. NM_001376009.1 → NP_001362938.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    8. NM_001376010.1 → NP_001362939.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    9. NM_001376011.1 → NP_001362940.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    10. NM_001387158.1 → NP_001374087.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    11. NM_001387159.1 → NP_001374088.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    12. NM_001387160.1 → NP_001374089.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    13. NM_001387161.1 → NP_001374090.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    14. NM_001387162.1 → NP_001374091.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    15. NM_001387163.1 → NP_001374092.1  schlafen family member 11

      Status: VALIDATED

      Source sequence(s)
      AC060766
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    16. NM_152270.4 → NP_689483.3  schlafen family member 11

      See identical proteins and their annotated locations for NP_689483.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All 16 variants encode the same protein.
      Source sequence(s)
      AC060766, BC052586, BM996330, BP245452
      Consensus CDS
      CCDS11294.1
      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
      Related
      ENSP00000312402.4, ENST00000308377.8
      Conserved Domains (2) summary
      PHA02782
      Location:15 → 348
      PHA02782; hypothetical protein; Provisional
      pfam09848
      Location:595 → 714
      DUF2075; Uncharacterized conserved protein (DUF2075)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      35350305..35373621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437042.1 → XP_047292998.1  schlafen family member 11 isoform X1

      UniProtKB/Swiss-Prot
      E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36298255..36321577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317762.1 → XP_054173737.1  schlafen family member 11 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001376012.1: Suppressed sequence

      Description
      NM_001376012.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7L1.2 GenPept UniProtKB/Swiss-Prot:Q7Z7L1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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