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    CCNE2 cyclin E2 [ Homo sapiens (human) ]

    Gene ID: 9134, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CCNE2provided by HGNC
    Official Full Name
    cyclin E2provided by HGNC
    Primary source
    HGNC:HGNC:1590
    See related
    Ensembl:ENSG00000175305 MIM:603775; AllianceGenome:HGNC:1590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYCE2
    Summary
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 6.8), bone marrow (RPKM 6.2) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCNE2 in Genome Data Viewer
    Location:
    8q22.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94880224..94896693, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (96005210..96021694, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95892452..95907429, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene epithelial splicing regulatory protein 1 Neighboring gene ribosomal protein S15a pseudogene 26 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:95731221-95732175 Neighboring gene dpy-19 like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27635 Neighboring gene integrator complex subunit 8 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:95906241-95906802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27636 Neighboring gene small nucleolar RNA U13 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:95960947-95961575 and GRCh37_chr8:95961576-95962205 Neighboring gene tumor protein p53 inducible nuclear protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down-regulating CCNE2 in pancreatic ductal adenocarcinoma. Yang J, et al. J Cell Mol Med, 2020 Apr. PMID 32141702, Free PMC Article
    2. Prognostic implication of morphology, cyclinE2 and proliferation in EBV-associated T/NK lymphoproliferative disease in non-immunocompromised hosts. Ng SB, et al. Orphanet J Rare Dis, 2014 Dec 5. PMID 25475054, Free PMC Article
    3. Deregulation of cyclin E2 expression and associated kinase activity in primary breast tumors. Payton M, et al. Oncogene, 2002 Dec 5. PMID 12466974
    4. [Expression and clinical significance of cyclin E2 in nasopharyngeal carcinoma]. Zhao GH, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012 Mar. PMID 22394640
    5. Clinical significance of CCNE2 protein and mRNA expression in thyroid cancer tissues. Liu CZ, et al. Adv Med Sci, 2020 Sep. PMID 33059229

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Screening Differential CircRNAs Expression Profiles Reveals the Regulatory Role of the has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 Signaling Axis in Bladder Carcinoma Progression.
      Title: Screening Differential CircRNAs Expression Profiles Reveals the Regulatory Role of the has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 Signaling Axis in Bladder Carcinoma Progression.
    2. Downregulation of miR-503-5p Promotes the Development of Pancreatic Cancer by Targeting Cyclin E2.
      Title: Downregulation of miR-503-5p Promotes the Development of Pancreatic Cancer by Targeting Cyclin E2.
    3. Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.
      Title: Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.
    4. E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-beta1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene.
      Title: E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-β1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene.
    5. Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2.
      Title: Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2.
    6. SP1-induced overexpression of LINC00520 facilitates non-small cell lung cancer progression through miR-577/CCNE2 pathway and predicts poor prognosis.
      Title: SP1-induced overexpression of LINC00520 facilitates non-small cell lung cancer progression through miR-577/CCNE2 pathway and predicts poor prognosis.
    7. Clinical significance of CCNE2 protein and mRNA expression in thyroid cancer tissues.
      Title: Clinical significance of CCNE2 protein and mRNA expression in thyroid cancer tissues.
    8. Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down-regulating CCNE2 in pancreatic ductal adenocarcinoma.
      Title: Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down-regulating CCNE2 in pancreatic ductal adenocarcinoma.
    9. CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression.
      Title: CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression.
    10. Nicotine-upregulated miR-30a arrests cell cycle in G1 phase by directly targeting CCNE2 in human periodontal ligament cells.
      Title: Nicotine-upregulated miR-30a arrests cell cycle in G1 phase by directly targeting CCNE2 in human periodontal ligament cells.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin E1-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin E2-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin E2-CDK2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G1/S-specific cyclin-E2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029611.1 RefSeqGene

      Range
      5054..20031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057749.3 → NP_477097.1  G1/S-specific cyclin-E2

      See identical proteins and their annotated locations for NP_477097.1

      Status: REVIEWED

      Source sequence(s)
      AF091433, BJ990268, DB547256
      Consensus CDS
      CCDS6264.1
      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
      Related
      ENSP00000309181.4, ENST00000308108.9
      Conserved Domains (2) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241 → 361
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      94880224..94896693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013958.2 → XP_016869447.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
      Related
      ENSP00000429089.1, ENST00000520509.5
      Conserved Domains (2) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241 → 361
      Cyclin_C; Cyclin, C-terminal domain

    2. XM_047422411.1 → XP_047278367.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020

    3. XM_017013959.2 → XP_016869448.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020
      UniProtKB/TrEMBL
      Q8WUE3
      Conserved Domains (2) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241 → 361
      Cyclin_C; Cyclin, C-terminal domain

    4. XM_011517366.3 → XP_011515668.1  G1/S-specific cyclin-E2 isoform X2

      Conserved Domains (1) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      96005210..96021694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361489.1 → XP_054217464.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020

    2. XM_054361491.1 → XP_054217466.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020

    3. XM_054361490.1 → XP_054217465.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/Swiss-Prot
      O95439, O96020

    4. XM_054361492.1 → XP_054217467.1  G1/S-specific cyclin-E2 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004702.2: Suppressed sequence

      Description
      NM_004702.2: This RefSeq was permanently suppressed because the transcript has insufficient support and is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_057735.1: Suppressed sequence

      Description
      NM_057735.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96020.1 GenPept UniProtKB/Swiss-Prot:O96020

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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