ERG9 bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ERG9
Official Full Name: bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase
Primary source: SGD:S000001233
Locus tag: YHR190W
See related: AllianceGenome:SGD:S000001233; FungiDB:YHR190W; VEuPathDB:YHR190W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables squalene synthase [NAD(P)H] activity. Involved in ergosterol biosynthetic process. Located in membrane. Is active in endoplasmic reticulum. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ERG9 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (484845..486179)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Restoration of the complete complementation phenotype was mapped to a 26-amino acid hinge region linking the catalytic and membrane-spanning domains specific to fungal squalene synthases.
Title: Mapping a kingdom-specific functional domain of squalene synthase.
Data show that engineered strains improved amorpha-4,11-diene by 2~5-fold over the reference strain with squalene synthase ERG9 under its native promoter.
Title: Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae.
The product distribution in the strains indicated that the energy barrier could be the reason that different metal ion-assisted electrophilic attacks initiated carbocation formation.
Title: ERG9 and COQ1 disruption reveals isoprenoids biosynthesis is closely related to mitochondrial function in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables squalene synthase [NAD(P)H] activity	IBA Inferred from Biological aspect of Ancestor more info
enables squalene synthase [NAD(P)H] activity	IDA Inferred from Direct Assay more info	PubMed
enables squalene synthase [NAD(P)H] activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ergosterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ergosterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ergosterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in farnesyl diphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in farnesyl diphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase

NP_012060.1

EC 2.5.1.21

Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

484845..486179

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179321.1 → NP_012060.1 TPA: bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012060.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLD8, P29704

UniProtKB/TrEMBL

A6ZT96, B5VKB8, C7GRL2, C8Z9Y9, E9P9H4, N1P4W6

Conserved Domains (1) summary

TIGR01559
Location:37 → 377

squal_synth; farnesyl-diphosphate farnesyltransferase