U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TRIM63 tripartite motif containing 63 [ Homo sapiens (human) ]

    Gene ID: 84676, updated on 9-Dec-2024

    Summary

    Official Symbol
    TRIM63provided by HGNC
    Official Full Name
    tripartite motif containing 63provided by HGNC
    Primary source
    HGNC:HGNC:16007
    See related
    Ensembl:ENSG00000158022 MIM:606131; AllianceGenome:HGNC:16007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRF; SMRZ; MURF1; MURF2; RNF28
    Summary
    This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
    Expression
    Biased expression in heart (RPKM 44.7) and esophagus (RPKM 2.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM63 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26051301..26067630, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25888705..25905036, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26377792..26394121, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26371640-26372208 Neighboring gene solute carrier family 30 member 2 Neighboring gene uncharacterized LOC105376910 Neighboring gene Sharpr-MPRA regulatory region 4919 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26405707-26405883 Neighboring gene VISTA enhancer hs2271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 473 Neighboring gene PDLIM1 interacting kinase 1 like Neighboring gene Sharpr-MPRA regulatory region 12487 Neighboring gene Sharpr-MPRA regulatory region 4586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26480925-26481654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26481655-26482384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26482385-26483114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26483115-26483844 Neighboring gene family with sequence similarity 110 member D

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32380

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables titin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to electrical stimulus involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle atrophy IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in M band IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in microtubule NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM63
    Names
    RING-type E3 ubiquitin transferase TRIM63
    iris ring finger protein
    muscle specific ring finger protein 2
    muscle-specific RING finger protein 1
    ring finger protein 28
    striated muscle RING zinc finger protein
    tripartite motif containing 63, E3 ubiquitin protein ligase
    tripartite motif-containing protein 63
    NP_115977.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033268.1 RefSeqGene

      Range
      5001..21331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_757

    mRNA and Protein(s)

    1. NM_032588.4NP_115977.2  E3 ubiquitin-protein ligase TRIM63

      See identical proteins and their annotated locations for NP_115977.2

      Status: REVIEWED

      Source sequence(s)
      AI351421, AL391650, BC080529, DA900348
      Consensus CDS
      CCDS273.1
      UniProtKB/Swiss-Prot
      B4DN95, Q5T2I1, Q969Q1, Q96BD3, Q96KD9, Q9BYV4
      UniProtKB/TrEMBL
      Q6NR77
      Related
      ENSP00000363390.3, ENST00000374272.4
      Conserved Domains (3) summary
      smart00336
      Location:120159
      BBOX; B-Box-type zinc finger
      cd00162
      Location:2382
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:188283
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      26051301..26067630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      25888705..25905036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)