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    Fmo3 flavin containing dimethylaniline monoxygenase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84493, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fmo3provided by RGD
    Official Full Name
    flavin containing dimethylaniline monoxygenase 3provided by RGD
    Primary source
    RGD:619761
    See related
    EnsemblRapid:ENSRNOG00000003620 AllianceGenome:RGD:619761
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables N,N-dimethylaniline monooxygenase activity; NADP binding activity; and amino acid binding activity. Involved in xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to human FMO3 (flavin containing dimethylaniline monoxygenase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 845.6), Liver (RPKM 691.8) and 3 other tissues See more
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    Genomic context

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    See Fmo3 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77838899..77868869, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (75309367..75334915, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80837418..80856214, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481523 Neighboring gene flavin containing monooxygenase 6 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene maestro heat-like repeat family member 9 Neighboring gene 40S ribosomal protein S8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes. Novick RM, et al. Drug Metab Dispos, 2008 Dec. PMID 18775983, Free PMC Article
    2. Oxidative metabolism of seleno-L-methionine to L-methionine selenoxide by flavin-containing monooxygenases. Krause RJ, et al. Chem Res Toxicol, 2006 Dec. PMID 17173378, Free PMC Article
    3. Cloning, sequencing, tissue distribution, and heterologous expression of rat flavin-containing monooxygenase 3. Lattard V, et al. Arch Biochem Biophys, 2001 Jul 1. PMID 11414682
    4. Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians. Dolan C, et al. BMC Med Genet, 2005 Dec 2. PMID 16324215, Free PMC Article
    5. Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney. Lattard V, et al. Biochem Pharmacol, 2002 Apr 15. PMID 11996886

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes.
      Title: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
    2. Results demonstrate many similar properties between rat hepatic and renal FMO3 forms and suggest that renal FMO3 may play an important role in kidney metabolism of xenobiotics containing sulfur and selenium atoms.
      Title: Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes.
    3. the relationship between gender and development in the expression of FMO3 in the liver and kidney was determined
      Title: Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93304

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables albendazole monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amino acid binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables trimethylamine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in taurine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in taurine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flavin-containing monooxygenase 3
    Names
    FMO 3
    dimethylaniline monooxygenase [N-oxide-forming] 3
    dimethylaniline oxidase 3
    flavin containing monooxygenase 3
    hepatic flavin-containing monooxygenase 3
    trimethylamine monooxygenase
    NP_445885.2
    XP_038947055.1
    XP_038947056.1
    XP_063128721.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053433.2 → NP_445885.2  flavin-containing monooxygenase 3

      See identical proteins and their annotated locations for NP_445885.2

      Status: PROVISIONAL

      Source sequence(s)
      BC087008
      UniProtKB/Swiss-Prot
      Q5PQV6, Q9EQ76
      UniProtKB/TrEMBL
      A0A0G2JSI0, A6IDB5
      Related
      ENSRNOP00000004864.4, ENSRNOT00000004864.7
      Conserved Domains (1) summary
      pfam00743
      Location:2 → 530
      FMO-like; Flavin-binding monooxygenase-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      77838899..77868869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272651.1 → XP_063128721.1  flavin-containing monooxygenase 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JSI0, A6IDB5

    2. XM_039091127.2 → XP_038947055.1  flavin-containing monooxygenase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5PQV6, Q9EQ76
      UniProtKB/TrEMBL
      A0A0G2JSI0, A6IDB5
      Conserved Domains (1) summary
      pfam00743
      Location:2 → 530
      FMO-like; Flavin-binding monooxygenase-like

    3. XM_039091128.2 → XP_038947056.1  flavin-containing monooxygenase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5PQV6, Q9EQ76
      UniProtKB/TrEMBL
      A0A0G2JSI0, A6IDB5
      Conserved Domains (1) summary
      pfam00743
      Location:2 → 530
      FMO-like; Flavin-binding monooxygenase-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQ76.1 GenPept UniProtKB/Swiss-Prot:Q9EQ76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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