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    COG0212 NagB/RpiA/CoA transferase-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844007, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COG0212
    Official Full Name
    NagB/RpiA/CoA transferase-like superfamily protein
    Primary source
    TAIR:AT1G76730
    Locus tag
    AT1G76730
    See related
    Araport:AT1G76730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Clusters of Orthologous group 212; F28O16.10; F28O16_10
    Summary
    Encodes a paralog of ATP-dependent folate salvage enzyme 5-formyltetrahydrofolate cycloligase (5-FCL) that is targeted to chloroplasts and to be required for embryo viability and lacks 5-FCL activity.
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    Genomic context

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    See COG0212 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (28802753..28804858, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene egg cell-secreted-like protein (DUF1278)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism. Pribat A, et al. Funct Integr Genomics, 2011 Sep. PMID 21538139, Free PMC Article
    2. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the 5-formyltetrahydrofolate cyclo-ligase protein from Arabidopsis thaliana lacked 5-formyltetrahydrofolate cyclo-ligase activity in vitro
      Title: A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_106323.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables 5-formyltetrahydrofolate cyclo-ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    NagB/RpiA/CoA transferase-like superfamily protein
    NP_565139.1
    • NagB/RpiA/CoA transferase-like superfamily protein; FUNCTIONS IN: catalytic activity, ATP binding, 5-formyltetrahydrofolate cyclo-ligase activity; INVOLVED IN: folic acid and derivative biosynthetic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 5-formyltetrahydrofolate cyclo-ligase (InterPro:IPR002698); Has 415 Blast hits to 415 proteins in 174 species: Archae - 92; Bacteria - 129; Metazoa - 119; Fungi - 6; Plants - 46; Viruses - 0; Other Eukaryotes - 23 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28802753..28804858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106323.4 → NP_565139.1  NagB/RpiA/CoA transferase-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GW33, Q9SRE0
      UniProtKB/TrEMBL
      A0A178WEK7, A0A5S9WUY5, A0A7G2E6Q4
      Conserved Domains (1) summary
      pfam01812
      Location:92 → 290
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SRE0.1

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