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    CRK2 cysteine-rich RLK (RECEPTOR-like protein kinase) 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843389, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRK2
    Official Full Name
    cysteine-rich RLK (RECEPTOR-like protein kinase) 2
    Primary source
    TAIR:AT1G70520
    Locus tag
    AT1G70520
    See related
    Araport:AT1G70520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALTERED SEED GERMINATION 6; ASG6; cysteine-rich RLK (RECEPTOR-like protein kinase) 2; F24J13.9; F24J13_9
    Summary
    Encodes a cysteine-rich receptor-like protein kinase.
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    Genomic context

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    See CRK2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (26584729..26587628, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene homeobox knotted-like protein Neighboring gene ncRNA Neighboring gene cysteine-rich RLK (RECEPTOR-like protein kinase) 3 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear pore complex components have temperature-influenced roles in plant growth and immunity. Zhang A, et al. Plant Cell Environ, 2020 Jun. PMID 32022936
    2. CRK2 Enhances Salt Tolerance by Regulating Callose Deposition in Connection with PLDα1. Hunter K, et al. Plant Physiol, 2019 Aug. PMID 31118265, Free PMC Article
    3. Transcriptional regulation of the CRK/DUF26 group of receptor-like protein kinases by ozone and plant hormones in Arabidopsis. Wrzaczek M, et al. BMC Plant Biol, 2010 May 25. PMID 20500828, Free PMC Article
    4. CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis. Kimura S, et al. Plant Cell, 2020 Apr. PMID 32034035, Free PMC Article
    5. Cosuppression of AtGELP22 and AtGELP23, two ubiquitinated target proteins of RING E3 ligase AtAIRP5, increases tolerance to drought stress in Arabidopsis. Cho NH, et al. Plant Mol Biol, 2023 Aug. PMID 37479835

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis.
      Title: CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis.
    2. inhibits GARU-GID1A interactions by phosphorylation of GARU, an E3 ubiquitin ligase that mediates degradation of GID1
      Title: Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105720.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within callose localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ozone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    cysteine-rich RLK (RECEPTOR-like protein kinase) 2
    NP_177209.1
    • cysteine-rich RLK (RECEPTOR-like protein kinase) 2 (CRK2); FUNCTIONS IN: kinase activity; INVOLVED IN: response to ozone; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Protein of unknown function DUF26 (InterPro:IPR002902), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 42 (TAIR:AT5G40380.1); Has 123193 Blast hits to 121713 proteins in 4855 species: Archae - 110; Bacteria - 13886; Metazoa - 45515; Fungi - 10581; Plants - 34413; Viruses - 473; Other Eukaryotes - 18215 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26584729..26587628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105720.4 → NP_177209.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177209.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9CAL3
      UniProtKB/TrEMBL
      A0A178WCD5, A0A5S9WT43
      Conserved Domains (3) summary
      smart00219
      Location:330 → 601
      TyrKc; Tyrosine kinase, catalytic domain
      cd14066
      Location:331 → 603
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam01657
      Location:56 → 133
      Stress-antifung; Salt stress response/antifungal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CAL3.1

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