Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Disease resistance protein (TIR-NBS-LRR class) family
Primary source: TAIR:AT1G65850
Locus tag: AT1G65850
See related: Araport:AT1G65850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F12P19.1; F12P19_1
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (24494678..24498826)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Disease resistance protein (TIR-NBS-LRR class) family

NP_001185325.1

Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: signal transduction, apoptosis, defense response, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, LP.02 two leaves visible, petal differentiation and expansion stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT5G38340.1).

NP_176760.2

Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: signal transduction, defense response, apoptosis, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, LP.02 two leaves visible, petal differentiation and expansion stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT5G38340.1); Has 26846 Blast hits to 18519 proteins in 671 species: Archae - 18; Bacteria - 1504; Metazoa - 2889; Fungi - 149; Plants - 21378; Viruses - 2; Other Eukaryotes - 906 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

24494678..24498826

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001334224.1 → NP_001321538.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WF92, A0A1P8AR74
NM_001198396.2 → NP_001185325.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185325.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654EX33, F4IBL4

Conserved Domains (6) summary

PLN03210
Location:46 → 1048

PLN03210; Resistant to P. syringae 6; Provisional

cd00116
Location:667 → 894

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:673 → 695

LRR_RI; leucine-rich repeat [structural motif]

pfam01582
Location:48 → 211

TIR; TIR domain

pfam07725
Location:649 → 667

LRR_3; Leucine Rich Repeat

cl17190
Location:245 → 275

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_105257.2 → NP_176760.2 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176760.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A654EX33, Q9SS05

Conserved Domains (2) summary

PLN03210
Location:24 → 1033

PLN03210; Resistant to P. syringae 6; Provisional

sd00033
Location:658 → 680

LRR_RI; leucine-rich repeat [structural motif]