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    SLC37A3 solute carrier family 37 member 3 [ Homo sapiens (human) ]

    Gene ID: 84255, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SLC37A3provided by HGNC
    Official Full Name
    solute carrier family 37 member 3provided by HGNC
    Primary source
    HGNC:HGNC:20651
    See related
    Ensembl:ENSG00000157800 MIM:619137; AllianceGenome:HGNC:20651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPX3
    Summary
    Enables xenobiotic transmembrane transporter activity. Involved in xenobiotic transmembrane transport. Located in endoplasmic reticulum membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 19.0), thyroid (RPKM 9.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC37A3 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (140333752..140398530, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (141647320..141712712, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140033552..140098330, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375534 Neighboring gene uncharacterized LOC124901758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26778 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:140063013-140063876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140067549-140068050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140068051-140068550 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26779 Neighboring gene RNA, 5S ribosomal pseudogene 247 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140089807-140090308 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140090309-140090808 Neighboring gene RNA, 5S ribosomal pseudogene 248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18711 Neighboring gene uncharacterized LOC124901759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140103431-140103932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140103933-140104432 Neighboring gene RAB19, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26781 Neighboring gene nucleoside diphosphate kinase, mitochondrial-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140143760-140144260

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The human sugar-phosphate/phosphate exchanger family SLC37. Bartoloni L, et al. Pflugers Arch, 2004 Feb. PMID 12811562
    2. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Yu Z, et al. Elife, 2018 May 10. PMID 29745899, Free PMC Article
    3. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. Pan CJ, et al. PLoS One, 2011. PMID 21949678, Free PMC Article
    4. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Palmieri M, et al. Hum Mol Genet, 2011 Oct 1. PMID 21752829
    5. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. Wang P, et al. J Clin Invest, 2019 Jul 25. PMID 31343991, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC37A3 protein localizes in lysosomes in HeLa cells
      Title: Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16367, MGC32939

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables glucose 6-phosphate:phosphate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in glucose-6-phosphate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in phosphate ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sugar phosphate exchanger 3
    Names
    solute carrier family 37 (glycerol-3-phosphate transporter), member 3
    sugar-phosphate exchange protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287498.2 → NP_001274427.1  sugar phosphate exchanger 3 isoform 3

      See identical proteins and their annotated locations for NP_001274427.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AK074823, BC046567, BM669953, DB481623
      Consensus CDS
      CCDS75669.1
      UniProtKB/Swiss-Prot
      Q8NCC5
      Related
      ENSP00000397481.2, ENST00000447932.6
      Conserved Domains (1) summary
      cl27298
      Location:14 → 463
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    2. NM_001363373.1 → NP_001350302.1  sugar phosphate exchanger 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC093087
      Conserved Domains (1) summary
      cl27298
      Location:14 → 410
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    3. NM_001363374.1 → NP_001350303.1  sugar phosphate exchanger 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK074823, BC046567, BM669953, DA750092, DB481623
      Conserved Domains (1) summary
      cl27298
      Location:14 → 358
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    4. NM_001363375.1 → NP_001350304.1  sugar phosphate exchanger 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AK074823, BC046567, BM669953, CX752660, DA064851, DB481623
      Conserved Domains (1) summary
      cl27298
      Location:14 → 398
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    5. NM_001363376.1 → NP_001350305.1  sugar phosphate exchanger 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC093087
      Conserved Domains (1) summary
      cl27298
      Location:14 → 391
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    6. NM_001363377.1 → NP_001350306.1  sugar phosphate exchanger 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC093087
      Conserved Domains (1) summary
      cl27298
      Location:14 → 189
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    7. NM_001363378.1 → NP_001350307.1  sugar phosphate exchanger 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AK074823, BC046567, BM669953, DA582415, DB481623
      Conserved Domains (1) summary
      cl27298
      Location:14 → 253
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    8. NM_032295.4 → NP_115671.1  sugar phosphate exchanger 3 isoform 2

      See identical proteins and their annotated locations for NP_115671.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three exons in the 3' coding region, resulting in a frameshift, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK074823, AL136583, BC028380, BM669953, DB481623
      Consensus CDS
      CCDS5858.1
      UniProtKB/Swiss-Prot
      Q8NCC5
      Related
      ENSP00000343358.3, ENST00000340308.7
      Conserved Domains (1) summary
      cd06174
      Location:84 → 341
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    9. NM_207113.3 → NP_996996.1  sugar phosphate exchanger 3 isoform 1

      See identical proteins and their annotated locations for NP_996996.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK074823, AL136583, BC028380, BM669953, DB481623
      Consensus CDS
      CCDS5859.1
      UniProtKB/Swiss-Prot
      Q6PIU7, Q86SS4, Q8NCC5, Q9BQG7
      Related
      ENSP00000321498.9, ENST00000326232.14
      Conserved Domains (1) summary
      cl27298
      Location:14 → 479
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    RNA

    1. NR_156489.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093087

    2. NR_156490.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093087

    3. NR_156491.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093087

    4. NR_156492.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093087, AK074823, AK299276, AL691676, BC046567, BM669953, CN261821, DC376346

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      140333752..140398530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420950.1 → XP_047276906.1  sugar phosphate exchanger 3 isoform X4

    2. XM_047420949.1 → XP_047276905.1  sugar phosphate exchanger 3 isoform X3

    3. XM_047420947.1 → XP_047276903.1  sugar phosphate exchanger 3 isoform X1

    4. XM_047420948.1 → XP_047276904.1  sugar phosphate exchanger 3 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      141647320..141712712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359216.1 → XP_054215191.1  sugar phosphate exchanger 3 isoform X4

    2. XM_054359215.1 → XP_054215190.1  sugar phosphate exchanger 3 isoform X3

    3. XM_054359213.1 → XP_054215188.1  sugar phosphate exchanger 3 isoform X1

    4. XM_054359214.1 → XP_054215189.1  sugar phosphate exchanger 3 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NCC5.2 GenPept UniProtKB/Swiss-Prot:Q8NCC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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