Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Disease resistance protein (TIR-NBS-LRR class) family
Primary source: TAIR:AT1G56520
Locus tag: AT1G56520
See related: Araport:AT1G56520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F25P12.102; F25P12_102
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (21174609..21179077, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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NM_001198323.1

Supported by ESTs:

NM_001333785.1

Supported by ESTs:

NM_001333787.1

Supported by ESTs:

NM_104528.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Disease resistance protein (TIR-NBS-LRR class) family

NP_001185252.1

Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: signal transduction, defense response, apoptosis, innate immune response; LOCATED IN: intrinsic to membrane; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT1G56510.1).

NP_176044.1

Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: signal transduction, apoptosis, defense response, innate immune response; LOCATED IN: intrinsic to membrane; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT1G56510.1); Has 16802 Blast hits to 12753 proteins in 523 species: Archae - 12; Bacteria - 1032; Metazoa - 1160; Fungi - 60; Plants - 14137; Viruses - 16; Other Eukaryotes - 385 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

21174609..21179077 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001333786.1 → NP_001321224.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AQ72, Q9FXA5
NM_104528.3 → NP_176044.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176044.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9C7W9, Q9FXA5

Conserved Domains (7) summary

smart00382
Location:208 → 338

AAA; ATPases associated with a variety of cellular activities

COG4886
Location:594 → 833

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:604 → 626

LRR_RI; leucine-rich repeat [structural motif]

pfam01582
Location:13 → 176

TIR; TIR domain

pfam07725
Location:603 → 622

LRR_3; Leucine Rich Repeat

pfam13191
Location:187 → 322

AAA_16; AAA ATPase domain

cl17190
Location:212 → 246

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001333785.1 → NP_001321226.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AQB1, Q9FXA5
NM_001198323.1 → NP_001185252.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185252.1

Status: REVIEWED

UniProtKB/TrEMBL

F4I552

Conserved Domains (5) summary

PLN03210
Location:1 → 950

PLN03210; Resistant to P. syringae 6; Provisional

sd00033
Location:604 → 626

LRR_RI; leucine-rich repeat [structural motif]

pfam01582
Location:13 → 176

TIR; TIR domain

pfam07725
Location:603 → 622

LRR_3; Leucine Rich Repeat

pfam13191
Location:187 → 322

AAA_16; AAA ATPase domain
NM_001333787.1 → NP_001321225.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AQ92