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    AT-IE histidine biosynthesis bifunctional protein (HISIE) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840076, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AT-IE
    Official Full Name
    histidine biosynthesis bifunctional protein (HISIE)
    Primary source
    TAIR:AT1G31860
    Locus tag
    AT1G31860
    See related
    Araport:AT1G31860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5M6.13; F5M6_13; HISN2; HISTIDINE BIOSYNTHESIS 2; PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE
    Summary
    encodes a bifunctional protein that has phosphoribosyl-ATP pyrophosphohydrolase (PRA-PH) and phosphoribosyl-AMP cyclohydrolase (PRA-CH) activities.
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    Genomic context

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    See AT-IE in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (11434060..11436607, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pre-mRNA-splicing factor of RES complex protein Neighboring gene DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a histidine biosynthetic gene in Arabidopsis encoding a polypeptide with two separate domains for phosphoribosyl-ATP pyrophosphohydrolase and phosphoribosyl-AMP cyclohydrolase. Fujimori K, et al. Plant Physiol, 1998 Sep. PMID 9733547, Free PMC Article
    2. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001332983.1
    NM_001332984.1
    NM_102923.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphoribosyl-AMP cyclohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosyl-AMP cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosyl-ATP diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosyl-ATP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-histidine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    histidine biosynthesis bifunctional protein (HISIE)
    NP_174469.1
    • AT-IE; FUNCTIONS IN: phosphoribosyl-AMP cyclohydrolase activity, phosphoribosyl-ATP diphosphatase activity; INVOLVED IN: histidine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phosphoribosyl-AMP cyclohydrolase (InterPro:IPR002496), Phosphoribosyl-ATP pyrophosphohydrolase (InterPro:IPR008179), Phosphoribosyl-ATP pyrophosphohydrolase-like (InterPro:IPR021130); Has 8084 Blast hits to 8082 proteins in 2164 species: Archae - 247; Bacteria - 4946; Metazoa - 2; Fungi - 173; Plants - 52; Viruses - 0; Other Eukaryotes - 2664 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11434060..11436607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102923.4 → NP_174469.1  histidine biosynthesis bifunctional protein (HISIE) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174469.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82768
      UniProtKB/TrEMBL
      A0A5S9WKE5, A0A7G2DXW5
      Conserved Domains (1) summary
      PLN02346
      Location:13 → 281
      PLN02346; histidine biosynthesis bifunctional protein hisIE

    2. NM_001332984.1 → NP_001322577.1  histidine biosynthesis bifunctional protein (HISIE) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AUE7

    3. NM_001332983.1 → NP_001322576.1  histidine biosynthesis bifunctional protein (HISIE) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WI36, A0A1P8AUF5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82768.1

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