CIPK23 CBL-interacting protein kinase 23 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CIPK23
Official Full Name: CBL-interacting protein kinase 23
Primary source: TAIR:AT1G30270
Locus tag: AT1G30270
See related: Araport:AT1G30270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCIPK23; CBL-interacting protein kinase 23; F12P21.6; F12P21_6; LKS1; LOW-K+-SENSITIVE 1; PKS17; SNF1-RELATED PROTEIN KINASE 3.23; SnRK3.23; SOS2-like protein kinase 17
Summary: Arabidopsis thaliana CBL-interacting protein kinase 23. CIPK23 serves as a positive regulator of the potassium transporter AKT1 by directly phosphorylating AKT1. CIPK23 is activated by the binding of two calcineurin B-like proteins, CBL1 and CBL9.
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Genomic context

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See CIPK23 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 14

Sequence:: Chromosome: 1; NC_003070.9 (10654800..10658924)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis.
Title: Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis.
CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
Title: CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
Title: The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH4(+) Balance in Arabidopsis Response to Low-K(+) Stress.
Title: STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH(4)(+) Balance in Arabidopsis Response to Low-K(+) Stress.
A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
Title: A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.
Title: CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.
The findings uncover additional pleiotropic roles of STOP1 mediated by CIPK23, which regulates various ion transporters including those regulating K+-homeostasis, which may induce a trade-off between drought tolerance and other traits.
Title: Sensitive to Proton Rhizotoxicity1 Regulates Salt and Drought Tolerance of Arabidopsis thaliana through Transcriptional Regulation of CIPK23.
CIPK23 occupies a key position in controlling ion balance and ion homeostasis in the plant cell.
Title: The Kinase CIPK23 Inhibits Ammonium Transport in Arabidopsis thaliana.
using mutants in known dormancy-related genes [DELAY OF GERMINATION 1 (DOG1), MOTHER OF FLOWERING TIME (MFT), CBL-INTERACTING PROTEIN KINASE 23 (CIPK23) and PHYTOCHROME A (PHYA)] components of the circadian clock are shown to be involved in coordination of the annual seed dormancy cycle.
Title: A laboratory simulation of Arabidopsis seed dormancy cycling provides new insight into its regulation by clock genes and the dormancy-related genes DOG1, MFT, CIPK23 and PHYA.
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
Title: AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001332883.1

Supported by ESTs:

NM_001332884.1

Supported by ESTs:

NM_102766.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within potassium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nutrient	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in stomatal movement	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: CBL-interacting protein kinase 23

NP_564353.1

CBL-interacting protein kinase 23 (CIPK23); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 9 (TAIR:AT1G01140.1); Has 132391 Blast hits to 130112 proteins in 4449 species: Archae - 167; Bacteria - 15551; Metazoa - 48688; Fungi - 13416; Plants - 32041; Viruses - 531; Other Eukaryotes - 21997 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

10654800..10658924

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102766.6 → NP_564353.1 CBL-interacting protein kinase 23 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564353.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93VD3, Q9C753

UniProtKB/TrEMBL

A0A178W2X4, A0A5S9WG58, A0A7G2DU57

Conserved Domains (2) summary

cd12195
Location:334 → 449

CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases

cd14663
Location:30 → 285

STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3
NM_001332883.1 → NP_001320726.1 CBL-interacting protein kinase 23 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8ANQ5, A0A7G2DU57
NM_001332884.1 → NP_001320727.1 CBL-interacting protein kinase 23 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W3M8, A0A1P8ANR3, A0A384KCC6, A0A7G2DU57