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    PAPP2C phytochrome-associated protein phosphatase type 2C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838835, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAPP2C
    Official Full Name
    phytochrome-associated protein phosphatase type 2C
    Primary source
    TAIR:AT1G22280
    Locus tag
    AT1G22280
    See related
    Araport:AT1G22280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    phytochrome-associated protein phosphatase type 2C; T16E15.10; T16E15_10
    Summary
    Encodes a phytochrome-associated protein, PAPP2C (phytochrome-associated protein phosphatase type 2C). PAPP2C interacts in the nucleus with phyA (phytochrome A) and phyB. Functions as a regulator of phytochrome-interacting factor PIF3 by dephosphorylating phytochromes in the nucleus.
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    Genomic context

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    See PAPP2C in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (7873867..7876018)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Myosin heavy chain-related protein Neighboring gene ncRNA Neighboring gene 14-3-3 family protein Neighboring gene general regulatory factor 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PAPP2C interacts with the atypical disease resistance protein RPW8.2 and negatively regulates salicylic acid-dependent defense responses in Arabidopsis. Wang WM, et al. Mol Plant, 2012 Sep. PMID 22334594
    2. A novel protein phosphatase indirectly regulates phytochrome-interacting factor 3 via phytochrome. Phee BK, et al. Biochem J, 2008 Oct 15. PMID 18564962
    3. Calcium/calmodulin-regulated receptor-like kinase CRLK1 interacts with MEKK1 in plants. Yang T, et al. Plant Signal Behav, 2010 Aug. PMID 20724845, Free PMC Article
    4. Tip Growth Defective1 interacts with the cellulose synthase complex to regulate cellulose synthesis in Arabidopsis thaliana. Lampugnani ER, et al. PLoS One, 2024. PMID 38358988, Free PMC Article
    5. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAPP2C interacts with RPW8.2 and negatively regulates salicylic acid-dependent defense responses.
      Title: PAPP2C interacts with the atypical disease resistance protein RPW8.2 and negatively regulates salicylic acid-dependent defense responses in Arabidopsis.
    2. Study show that PAPP2C interacts in the nucleus with phyA and phyB, and functions as a regulator of PIF3 by dephosphorylating phytochromes in the nucleus. [PAPP2C]
      Title: A novel protein phosphatase indirectly regulates phytochrome-interacting factor 3 via phytochrome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102079.5
    NM_202154.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within red light signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    phytochrome-associated protein phosphatase type 2C
    NP_001185062.1
    • phytochrome-associated protein phosphatase type 2C (PAPP2C); CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT1G34750.1).
    NP_564165.1
    • phytochrome-associated protein phosphatase type 2C (PAPP2C); FUNCTIONS IN: protein serine/threonine phosphatase activity, phosphoprotein phosphatase activity; INVOLVED IN: protein amino acid dephosphorylation, red light signaling pathway; LOCATED IN: nucleus, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT1G34750.1); Has 8206 Blast hits to 8190 proteins in 1131 species: Archae - 16; Bacteria - 1989; Metazoa - 1496; Fungi - 741; Plants - 2625; Viruses - 11; Other Eukaryotes - 1328 (source: NCBI BLink).
    NP_973883.1
    • phytochrome-associated protein phosphatase type 2C; FUNCTIONS IN: protein serine/threonine phosphatase activity, phosphoprotein phosphatase activity; INVOLVED IN: protein amino acid dephosphorylation, red light signaling pathway; LOCATED IN: nucleus, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT1G34750.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7873867..7876018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198133.1 → NP_001185062.1  phytochrome-associated protein phosphatase type 2C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I1B4
      Conserved Domains (1) summary
      cd00143
      Location:32 → 286
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. NM_102079.5 → NP_564165.1  phytochrome-associated protein phosphatase type 2C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3ED74, Q8LFF8, Q9LME4
      UniProtKB/TrEMBL
      A0A178WBX4, A0A5S9VIA9
      Conserved Domains (1) summary
      cd00143
      Location:32 → 280
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    3. NM_202154.2 → NP_973883.1  phytochrome-associated protein phosphatase type 2C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LME4
      Conserved Domains (1) summary
      cd00143
      Location:32 → 191
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LME4.1

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