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    ABCI14 trigalactosyldiacylglycerol 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838568, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCI14
    Official Full Name
    trigalactosyldiacylglycerol 1
    Primary source
    TAIR:AT1G19800
    Locus tag
    AT1G19800
    See related
    Araport:AT1G19800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP-binding cassette I14; F14P1.27; F14P1_27; TGD1; trigalactosyldiacylglycerol 1
    Summary
    Encodes a permease-like protein involved in lipid transfer from the ER to the chloroplast, more specifically, transfer of phosphatidate across the chloroplast inner membrane. Mutant leaves accumulate trigalactosyldiacylglycerol, triacylglycerol and phosphatidate. Chloroplast lipids are altered in their fatty acid composition and as a consequence the development of chloroplasts in the mutants are impacted. The mutant seeds has a higher abortion rate. Mutations in this gene suppress the low temperature-induced phenotype of Arabidopsis tocopherol-deficient mutant vte2.
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    Genomic context

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    See ABCI14 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (6846338..6848128)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene purine permease 14 Neighboring gene cyclic nucleotide gated channel 8 Neighboring gene SHI-related sequence 7 Neighboring gene miscRNA Neighboring gene SAUR-like auxin-responsive protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of the TGD1 chloroplast envelope protein affects phosphatidate metabolism in Arabidopsis. Xu C, et al. Plant Cell, 2005 Nov. PMID 16199613, Free PMC Article
    2. TGD1, -2, and -3 proteins involved in lipid trafficking form ATP-binding cassette (ABC) transporter with multiple substrate-binding proteins. Roston RL, et al. J Biol Chem, 2012 Jun 15. PMID 22544736, Free PMC Article
    3. Genetic analysis of Arabidopsis mutants impaired in plastid lipid import reveals a role of membrane lipids in chloroplast division. Fan J, et al. Plant Signal Behav, 2011 Mar. PMID 21358271, Free PMC Article
    4. A small ATPase protein of Arabidopsis, TGD3, involved in chloroplast lipid import. Lu B, et al. J Biol Chem, 2007 Dec 7. PMID 17938172
    5. Arabidopsis TRIGALACTOSYLDIACYLGLYCEROL5 Interacts with TGD1, TGD2, and TGD4 to Facilitate Lipid Transfer from the Endoplasmic Reticulum to Plastids. Fan J, et al. Plant Cell, 2015 Oct. PMID 26410300, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TGD1, -2, and -3 proteins involved in lipid trafficking form ATP-binding cassette (ABC) transporter with multiple substrate-binding proteins.
      Title: TGD1, -2, and -3 proteins involved in lipid trafficking form ATP-binding cassette (ABC) transporter with multiple substrate-binding proteins.
    2. The tgd1-1 fad6 and tgd4-3 fad6 double mutants were deficient in polyunsaturated fatty acids in chloroplast membrane lipids, and severely compromised in the biogenesis of photosynthetic membrane systems.
      Title: Genetic analysis of Arabidopsis mutants impaired in plastid lipid import reveals a role of membrane lipids in chloroplast division.
    3. TGD3 is the missing ATPase component of a lipid transporter involving TGD1 and TGD2 required for the biosynthesis of ER-derived thylakoid lipids in Arabidopsis.
      Title: A small ATPase protein of Arabidopsis, TGD3, involved in chloroplast lipid import.
    4. As even partial disruption of TGD1 function has drastic consequences on central lipid metabolism, the tgd1 mutant provides a tool to explore regulatory mechanisms governing lipid homeostasis and lipid trafficking in plants.
      Title: Mutation of the TGD1 chloroplast envelope protein affects phosphatidate metabolism in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332407.1
    NM_001332408.1
    NM_001332409.1
    NM_101836.4
    NM_202139.3
    NM_202140.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lipid transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast inner membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    trigalactosyldiacylglycerol 1
    NP_173410.1
    • trigalactosyldiacylglycerol 1 (TGD1); FUNCTIONS IN: lipid transporter activity; INVOLVED IN: lipid transport; LOCATED IN: chloroplast outer membrane, chloroplast, chloroplast inner membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF140 (InterPro:IPR003453); Has 5322 Blast hits to 5322 proteins in 1401 species: Archae - 0; Bacteria - 4515; Metazoa - 1; Fungi - 0; Plants - 48; Viruses - 0; Other Eukaryotes - 758 (source: NCBI BLink).
    NP_973868.1
    • trigalactosyldiacylglycerol 1 (TGD1); FUNCTIONS IN: lipid transporter activity; INVOLVED IN: lipid transport; LOCATED IN: chloroplast outer membrane, chloroplast, chloroplast inner membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF140 (InterPro:IPR003453); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_973869.1
    • trigalactosyldiacylglycerol 1 (TGD1); FUNCTIONS IN: lipid transporter activity; INVOLVED IN: lipid transport; LOCATED IN: chloroplast outer membrane, chloroplast, chloroplast inner membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF140 (InterPro:IPR003453); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6846338..6848128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202140.2 → NP_973869.1  trigalactosyldiacylglycerol 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973869.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L4R0, Q9FXH8
      UniProtKB/TrEMBL
      A0A178WKD3, A0A5S9V6M4
      Conserved Domains (1) summary
      PLN03100
      Location:50 → 341
      PLN03100; Permease subunit of ER-derived-lipid transporter; Provisional

    2. NM_101836.4 → NP_173410.1  trigalactosyldiacylglycerol 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173410.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L4R0, Q9FXH8
      UniProtKB/TrEMBL
      A0A178WKD3, A0A5S9V6M4
      Conserved Domains (1) summary
      PLN03100
      Location:50 → 341
      PLN03100; Permease subunit of ER-derived-lipid transporter; Provisional

    3. NM_001332407.1 → NP_001322722.1  trigalactosyldiacylglycerol 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L4R0, Q9FXH8
      UniProtKB/TrEMBL
      A0A178WKD3, A0A5S9V6M4
      Conserved Domains (1) summary
      PLN03100
      Location:50 → 341
      PLN03100; Permease subunit of ER-derived-lipid transporter; Provisional

    4. NM_001332408.1 → NP_001322720.1  trigalactosyldiacylglycerol 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L4R0, Q9FXH8
      UniProtKB/TrEMBL
      A0A178WKD3, A0A5S9V6M4
      Conserved Domains (1) summary
      PLN03100
      Location:50 → 341
      PLN03100; Permease subunit of ER-derived-lipid transporter; Provisional

    5. NM_001332409.1 → NP_001322721.1  trigalactosyldiacylglycerol 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L4R0, Q9FXH8
      UniProtKB/TrEMBL
      A0A178WKD3, A0A5S9V6M4
      Conserved Domains (1) summary
      PLN03100
      Location:50 → 341
      PLN03100; Permease subunit of ER-derived-lipid transporter; Provisional

    6. NM_202139.3 → NP_973868.1  trigalactosyldiacylglycerol 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973868.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L4R0, Q9FXH8
      UniProtKB/TrEMBL
      A0A178WKD3, A0A5S9V6M4
      Conserved Domains (1) summary
      PLN03100
      Location:50 → 341
      PLN03100; Permease subunit of ER-derived-lipid transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L4R0.1

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