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    MKK7 MAP kinase kinase 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838416, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MKK7
    Official Full Name
    MAP kinase kinase 7
    Primary source
    TAIR:AT1G18350
    Locus tag
    AT1G18350
    See related
    Araport:AT1G18350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMKK7; BUD1; BUSHY AND DWARF 1; F15H18.14; F15H18_14; MAP kinase kinase 7; MAP KINASE KINASE7
    Summary
    MAP kinase kinase7. Member of plant mitogen-activated protein kinase kinase group D. Negative regulator of polar auxin transport. Overexpression leads to activation of basal and systemic acquired resistance.
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    Genomic context

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    See MKK7 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (6315636..6316738)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene basal transcription factor complex subunit-like protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ATP binding microtubule motor family protein Neighboring gene Serine/Threonine kinase family catalytic domain protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased expression of MAP KINASE KINASE7 causes deficiency in polar auxin transport and leads to plant architectural abnormality in Arabidopsis. Dai Y, et al. Plant Cell, 2006 Feb. PMID 16377756, Free PMC Article
    2. Phosphatidic acid promotes the activation and plasma membrane localization of MKK7 and MKK9 in response to salt stress. Shen L, et al. Plant Sci, 2019 Oct. PMID 31481213
    3. Overexpression of Arabidopsis MAP kinase kinase 7 leads to activation of plant basal and systemic acquired resistance. Zhang X, et al. Plant J, 2007 Dec. PMID 17908155
    4. Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis. Jia W, et al. PLoS Biol, 2016 Sep. PMID 27618482, Free PMC Article
    5. The Raf-like MAPKKKs STY8, STY17, and STY46 negatively regulate Botrytis cinerea resistance by limiting MKK7 protein accumulation in Arabidopsis. Chen L, et al. Plant J, 2024 Mar. PMID 38059690

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that phosphatidic acid (PA) binds to MKK7 and MKK9, increases their kinase activity and plasma membrane localization during Arabidopsis response to salt stress.
      Title: Phosphatidic acid promotes the activation and plasma membrane localization of MKK7 and MKK9 in response to salt stress.
    2. A novel mechanism for PIN1 phosphorylation involving MKK7 and MPK6 in shoot branching regulation in Arabidopsis.
      Title: Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis.
    3. MKK4, MKK5, MKK7, and MKK9, are responsible for the activation of MPK3 and MPK6 by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK signaling through MKK4/5/7/9-MPK3/6 cascades.
      Title: Mitogen-activated protein kinase pathways are required for melatonin-mediated defense responses in plants.
    4. bud1 (bushy and dwarf1) phenotype is a result of increased expression of Arabidopsis MAP KINASE KINASE7 (MKK7), a member of plant mitogen-activated protein kinase kinase group D. [MKK7] [BUD1]
      Title: Increased expression of MAP KINASE KINASE7 causes deficiency in polar auxin transport and leads to plant architectural abnormality in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101693.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen-pistil interaction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance, salicylic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAP kinase kinase 7
    NP_173271.1
    • MAP kinase kinase 7 (MKK7); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 9 (TAIR:AT1G73500.1); Has 127926 Blast hits to 126631 proteins in 4862 species: Archae - 158; Bacteria - 14837; Metazoa - 47772; Fungi - 12215; Plants - 31900; Viruses - 488; Other Eukaryotes - 20556 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6315636..6316738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101693.3 → NP_173271.1  MAP kinase kinase 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173271.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0ME75, Q9LPQ3
      UniProtKB/TrEMBL
      A0A178W604, A0A5S9UZS3
      Conserved Domains (1) summary
      cd06623
      Location:43 → 305
      PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LPQ3.1

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