SCRM2 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SCRM2
Official Full Name: basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Primary source: TAIR:AT1G12860
Locus tag: AT1G12860
See related: Araport:AT1G12860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F13K23.12; F13K23_12; ICE2; INDUCER OF CBF EXPRESSION 2; SCREAM 2
Summary: Encodes ICE2 (Inducer of CBF Expression 2), a transcription factor of the bHLH family that participates in the response to deep freezing through the cold acclimation-dependent pathway. Overexpression of ICE2 results in increased tolerance to deep freezing stress after cold acclimation.
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Genomic context

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See SCRM2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (4384304..4386651)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

unified ICE-CBF pathway provides transcriptional feedback control of freezing tolerance during cold acclimation
Title: The unified ICE-CBF pathway provides a transcriptional feedback control of freezing tolerance during cold acclimation in Arabidopsis.
ICE2 gene has originated from a duplication event about 17.9MYA followed by sub- and neofunctionalization of the ancestral ICE1 gene.
Title: Arabidopsis thaliana ICE2 gene: phylogeny, structural evolution and functional diversification from ICE1.
Jasmonate functions as a critical upstream signal of the ICE-CBF/DREB1 pathway to positively regulate Arabidopsis freezing tolerance.
Title: Jasmonate regulates the inducer of cbf expression-C-repeat binding factor/DRE binding factor1 cascade and freezing tolerance in Arabidopsis.
These results suggested that the CBF1 transcription factor, known as one of the regulators of the cold stress response, has a dominant role in providing freezing tolerance in transgenic plants characterized by overexpression of ICE2.
Title: Identification of ICE2, a gene involved in cold acclimation which determines freezing tolerance in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001332054.1

Supported by ESTs:

NM_101157.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within guard mother cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to freezing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: basic helix-loop-helix (bHLH) DNA-binding superfamily protein

NP_172746.2

SCREAM 2 (SCRM2); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to freezing, guard mother cell differentiation, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT3G26744.4); Has 4150 Blast hits to 4134 proteins in 202 species: Archae - 0; Bacteria - 1; Metazoa - 48; Fungi - 52; Plants - 4003; Viruses - 0; Other Eukaryotes - 46 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

4384304..4386651

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001332053.1 → NP_001320453.1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WKR6, A0A1P8AMV9, A0A5S9U2N6
NM_101157.3 → NP_172746.2 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172746.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LPW3

UniProtKB/TrEMBL

A0A178WKR6, A0A5S9U2N6

Conserved Domains (3) summary

cd04873
Location:379 → 420

ACT_UUR-ACR-like; ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD

cd11443
Location:266 → 337

bHLH_AtAMS_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores (AMS) and similar proteins

cl29764
Location:305 → 381

Cathelicidins
NM_001332054.1 → NP_001320452.1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AMU2