FRO1 NADH-ubiquinone oxidoreductase-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FRO1
Official Full Name: NADH-ubiquinone oxidoreductase-like protein
Primary source: TAIR:AT5G67590
Locus tag: AT5G67590
See related: Araport:AT5G67590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: FROSTBITE1; K9I9.16; K9I9_16
Summary: Mutant leaves have a reduced capacity for cold acclimation, appear water-soaked, leak electrolytes, and accumulate reactive oxygen species constitutively. Encode a protein with high similarity to the 18-kD Fe-S subunit of complex I (NADH dehydrogenase, EC 1.6.5.3) in the mitochondrial electron transfer chain.
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Genomic context

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See FRO1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 5

Sequence:: Chromosome: 5; NC_003076.8 (26957915..26959557)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial perturbations related to a defect in complex I in the Arabidopsis thaliana frostbite1 (fro1) mutant, carrying a point mutation in the 8-kD Fe-S subunit of NDUFS4 protein, alter aspects of fundamental carbon metabolism, which is manifested as stunted growth. The responses of fro1 plants to NH treatment were consistent with the inhibition of a form of programmed cell death.
Title: Nitrogen Source Dependent Changes in Central Sugar Metabolism Maintain Cell Wall Assembly in Mitochondrial Complex I-Defective frostbite1 and Secondarily Affect Programmed Cell Death.
Data show no major differences in the mitochondrial proteomes, cellular metabolomes, or transcriptomes between ndufv1 (At5g08530) and ndufs4 (At5g67590) mutants.
Title: Complete Mitochondrial Complex I Deficiency Induces an Up-Regulation of Respiratory Fluxes That Is Abolished by Traces of Functional Complex I.
The growth of fro1 plants increased under ammonium nutrition. Ammonium nutrition increased the reduction level of pyridine nucleotides in the leaves of wild-type plants, but not in the leaves of fro1 mutant plants.
Title: In comparison with nitrate nutrition, ammonium nutrition increases growth of the frostbite1 Arabidopsis mutant.
Removal of the single protein subunit NDUFS4 prevents assembly of complex I of the respiratory chain and removes its function from mitochondria without pleiotropic effects on other respiratory components. [NDUFS4]
Title: Remodeled respiration in ndufs4 with low phosphorylation efficiency suppresses Arabidopsis germination and growth and alters control of metabolism at night.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_126159.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cobalt ion binding	HDA more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cold acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plastid	HDA more info	PubMed
part_of respiratory chain complex I	HDA more info	PubMed

General protein information

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Preferred Names: NADH-ubiquinone oxidoreductase-like protein

NP_201560.1

FROSTBITE1 (FRO1); CONTAINS InterPro DOMAIN/s: ETC complex I subunit conserved region (InterPro:IPR006885); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

26957915..26959557

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126159.4 → NP_201560.1 NADH-ubiquinone oxidoreductase-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201560.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LC28, Q9FJW4

UniProtKB/TrEMBL

A0A178UKD2, A0A5S9YHW4

Conserved Domains (1) summary

pfam04800
Location:53 → 149

ETC_C1_NDUFA4; ETC complex I subunit conserved region